Substituted pyrimidines, process for their preparation, and their use as pesticides and fungicides

ABSTRACT

The invention relates to compounds of the formula defined in the description, X is NH or oxygen and E is a bond or a 1- to 4-membered carbon chain, to a process for their preparation, to agents containing them, and to their use in the control of pests and as fungicides.

DESCRIPTION

The invention relates to novel substituted 4-amino- and 4-alkoxypyrimidines, to processes for their preparation and to their use as pesticides, in particular as insecticides, acaricides and fungicides.

It has already been disclosed that certain substituted 4-aminopyrimidines have a good fungicidal, acaricidal and insecticidal activity (cf. EP-A-57,440, EP-A-196,524, EP-A-264,217, EP-A-276,406, EP-A-323,757, EP-A-326,328, EP-A-326,329, EP-A-326,330, EP-A-356,158, EP-A-370,704, EP-A-411,634, EP-A-424,125, EP-A-452,002, EP-A-459,611, EP-A-447,891). However, the biological activity of these compounds is not satisfactory in all fields of application, in particular when low dosage rates and concentrations are used.

Novel substituted 4-amino- and 4-alkoxypyrimidines of the formula I have been found, ##STR2## in which

R¹ is hydrogen, halogen, (C₁ -C₄)-alkyl or (C₃ -C₆)-cycloalkyl,

R² is hydrogen, (C₁ -C₄ )-alkyl, halogen, (C₁ -C₄)-haloalkyl, (C₁ -C₄)-alkoxy, (C₁ -C₄)-haloalkoxy, (C₁ -C₄)-alkoxy-(C₁ -C₄)-alkyl, (C₁ -C₄)-alkylthio, (C₁ -C₄)-alkylthio-(C₁ -C₄)-alkyl, (C₁ -C₄)-alkylamino or di-(C₁ -C₄)-alkylamino,

R³ is hydrogen, (C₁ -C₄)-alkyl, (C₁ -C₄)-alkoxy, (C₁ -C₄)-haloalkoxy, halogen, (C₁ -C₄)-alkylthio, amino, (C₁ -C₄)-alkylamino or di-(C₁ -C₄)-alkylamino or

R² and R³ together with the carbon atoms to which they are bonded form an unsaturated 5- or 6-membered isocyclic ring which, if it is a 5-membered ring, can contain an oxygen or sulfur atom in place of CH₂ and which is optionally substituted by 1, 2 or 3 identical or different radicals, these radicals being (C₁ -C₄)-alkyl, (C₁ -C₄)-alkoxy, (C₁ -C₄)-haloalkyl, preferably trifluoromethyl, (C₁ -C₄)-haloalkoxy and/or halogen, or

R² and R³ together with the carbon atoms to which they are bonded form a saturated 5-, 6- or 7-membered isocyclic ring which can contain an oxygen or sulfur atom in place of CH₂ and which is optionally substituted by 1, 2 or 3 (C₁ -C₄)-alkyl groups,

X is NH or oxygen,

E is a direct bond or a straight-chain or branched (C₁ -C₄)-alkanediyl group, preferably a direct bond,

Q has the meaning Q¹ and

Q¹ is a cycloalkyl group of the formula II ##STR3##

in which n is an integer from 2 to 7,

R⁴ and R⁵ are identical or different and are in each case hydrogen, (C₁ -C₁₂)-alkyl, (C₃ -C₈)-cycloalkyl, (C₃ -C₈)-cycloalkyl-(C₁ -C₄) -alkyl,)-alkyl, (C₁ -C₈)-alkoxy, (C₃ -C₈)-cycloalkoxy, (C₁ -C₄)-alkoxy-(C₁ -C₄)-alkyl, (C₃ -C₈)-cycloalkyl-(C₁ -C₄)-alkoxy, tri-(C₁ -C₈)-alkylsilyl, preferably dimethyl-(C₁ -C₈)-alkylsily or triethylsilyl, di-(C₁ -C₈)-alkyl-(C₁ -C₈)-cycloalkylsilyl, preferably dimethylcyclohexylsilyl, di-(C₁ -C₈)-alkyl(phenyl-(C₁ -C₄)-alkyl)-silyl, preferably dimethyl-(phenyl-(C₁ -C₄)-alkyl) silyl, di-(C₁ -C₈)-alkyl-(C₁ -C₄)-haloalkylsilyl, preferably dimethyl-(C₁ -C₄)-haloalkylsilyl, dimethylphenylsilyl, (C₁ -C₄)-haloalkyl, halogen, (C₁ -C₄)-haloalkoxy, heteroaryl, phenyl, phenyl-(C₁ -C₄)-alkyl, benzyloxy, benzyloxy-(C₁ -C₄)-alkyl, benzylthio, phenylthio or phenoxy, it being possible for the phenyl rings in the seven last-mentioned radicals to be unsubstituted or provided with one or two substituents and these suhstituents are identical or different and can be in each case (C₁ -C₈)-alkyl, (C₃ -C₈)-cycloalkyl, (C₁ -C₄)-haloalkyl, preferably trifluoromethyl, halogen, (C₁ -C₄)-dialkylamino, (C₁ -C₄)-alkylthio, (C₁ -C₈)-alkoxy, (C₁ -C₄)-haloalkoxy, (C₁ -C₄)-alkoxy-(C₁ -C₄)-alkoxy, H₅ C₂ --O--[CH₂ --CH₂ --O--]_(x), 2-(tetrahydro-2H-pyran-2-yloxy)-ethoxy, (C₂ -C₈)-alkenyl, (C₂ -C₈)-alkynyl, benzyloxy which in the phenyl radical optionally carries one or two identical or different substituents selected from the group comprising (C₁ -C₄)-alkyl, (C₁ -C₄)-haloalkyl, (C₁ -C₄)-alkoxy, (C₁ -C₄)-haloalkoxy and halogen, or tri-(C₁ -C₄)-alkylsilylmethoxy, preferably dimethyl-(C₁ -C₄)-alkylsilylmethoxy, (C₃ -C₈)-cycloalkyl-(C₁ -C₄)-alkoxy, 1,3-dioxolan-2 -ylmethoxy, tetrahydrofuran-2-ylmethoxy or tetrahydro-2H-pyran-2-ylmethoxy, where, both, R⁴ and R⁵ do not coincidentally denote hydrogen, and where, in two adjacent substituents which are identical or different and are selected from the group comprising (C₁ -C₈)-alkyl and (C₁ -C₈)-alkoxy, in each case one hydrogen atom can be replaced by a joint carbon-carbon bond which links these two substituents, or

R⁴ and R⁵ together with the cycloalkyl group form a 3-8-membered spirocyclic, preferably saturated spirocyclic, ring system which can contain oxygen or sulfur in place of one or two CH₂ groups or

R⁴ and R⁵ together with the carbon atoms carrying them form a fused 5- or 6-membered, preferably saturated isocycle, in particular a cyclopentane or cyclohexane system,

X is 2, 3 or 4, preferably 2, or

Q has the meaning Q² and

Q² is a group of the formula III ##STR4## in which R⁶ is a group of the formula Z-W and Z is a direct bond or carbonyl or sulfonyl and W is an aryl or heteroaryl group which can be unsubstituted or provided with one or two substituents and these substituents are identical or different and are in each case (C₁ -C₈)-alkyl, (C₃ -C₈)-cycloalkyl, trifluoromethyl, halogen, (C₁ -C₄)-alkoxy, (C₁ -C₄)-dialkylamino or (C₁ -C₄)-alkylthio.

If Q has the meaning Q¹, R² and R³ together with the carbon atoms carrying them form an unsaturated 6-membered isocyclic ring and R⁴ and R⁵ form a fused 5- or 6-membered ring, then the meaning 5-membered ring is preferred for the two last-mentioned radicals.

If Q has the meaning Q¹, and R² and R³ together with the carbon atoms carrying them form a furan or thiophene system, then Q¹ is preferably not (C₃ -C₈)-cycloalkyl which is optionally substituted and the substituents are in particular alkyl such as (C₁ -C₄)-alkyl, alkoxy such as (C₁ -C₄)-alkoxy, haloalkyl such as (C₁ -C₄)-haloalkyl, haloalkoxy such as (C₁ -C₄)-haloalkoxy or halogen.

Preferred compounds of the formula I are those in which

R¹ is hydrogen, methyl or cyclopropyl,

R² is (C₁ -C₄)-alkyl, chlorine, methoxy, ethoxy or methoxymethyl,

R³ is hydrogen, (C₁ -C₃)-alkyl, methoxy, ethoxy or halogen or

R² and R³ together with the carbon atoms to which they are bonded form an unsaturated 5- or 6-membered ring which can contain an oxygen or sulfur atom, or R² and R³ together with the carbon atoms to which they are bonded form a saturated 5- or 6-membered ring which can contain a sulfur atom,

Q has the meaning Q¹ or Q², in particular those compounds of the formula I in which

R¹ is hydrogen or methyl,

R² is methyl, ethyl, methoxy, ethoxy or methoxymethyl,

R³ is methyl, ethyl, methoxy, chlorine or bromine, or

R² and R³ together with the carbon atoms to which they are bonded form the quinazoline system, or

R² and R³ together with the carbon atoms to which they are bonded form a saturated 6-membered ring which can contain a sulfur atom and

Q has the meaning Q¹ or Q², preferably those compounds of the formula I in which

E is a direct bond,

R¹ is hydrogen,

R² is methyl, ethyl or methoxymethyl,

R³ is chlorine, bromine or methoxy or

R² and R³ together with the carbon atoms to which they are bonded form the quinazoline system which can be substituted by fluorine, chlorine, bromine or methyl, or

R² and R³ together with the pyrimidine ring form the 5,6,7,8-tetrahydroquinazoline system or the 5,6-dihydro-7H-thiopyrano[2,3-d]pyrimidine or the 5,6-dihydro-8H-thiopyrano[3,4-d]pyrimidine system ##STR5## and

Q has the meaning Q¹ or Q².

Very particularly preferred compounds of the formula I are those in which

E is a direct bond,

R¹ is hydrogen,

R² is methoxymethyl and R³ is methoxy or

R² is methyl or ethyl and R³ is chlorine or bromine or

R² and R³ together with the carbon atom to which they are bonded form a quinazoline system which is substituted by fluorine, chlorine or methyl, or form a 5,6,7,8-tetrahydroquinazoline system and

Q has the meaning Q¹, in particular those compounds of the formula I in which

E is a direct bond,

R¹ is hydrogen,

R² is methoxymethyl and R³ is methoxy or

R² is ethyl and R³ is chlorine or

R² and R³ together with the carbon atom to which they are bonded form a quinazoline or a 5,6,7,8-tetrahydroquinazoline system and

Q is a cycloalkyl group of the formula II which is substituted in the 3- or 4-position and in which n is 4 or 5,

R⁴ is (C₃ -C₈)-alkyl, cyclopentyl, cyclohexyl, phenyl or phenoxy, it being possible for the two last-mentioned radicals to be unsubstituted or provided with one or two substituents which can be identical or different and which are fluorine, chlorine, bromine, (C₁ -C₄)-alkyl, (C₁ -C₄)-alkoxy, trifluoromethyl, (C₁ -C₂)-haloalkoxy, cyclohexyl, 2-ethoxyethoxy, methylthio or dimethylamino, and

R⁵ is hydrogen.

Other very particularly preferred compounds of the formula I are those in which

E is a direct bond,

R¹ is hydrogen,

R² is methoxymethyl and R³ is methoxy or

R² is ethyl and R³ is chlorine, or

R² and R³ together with the carbon atoms to which they are bonded form a quinazoline or a 5,6,7,8-tetrahydroquinazoline system,

Q has the meaning Q¹ and

Q¹ is cyclohexyl which is substituted in the 4-position, and E and the substituent in the 4-position of the cyclohexyl are in the cis position relative to each other,

R⁴ is as defined above and

R⁵ is preferably hydrogen.

In the above formula I, "halogen" is to be understood as meaning a fluorine, chlorine, bromine or iodine atom, preferably a fluorine, chlorine or bromine atom, the term "(C₁ -C₄)-alkyl" is to be understood as meaning an unbranched or branched hydrocarbon radical having 1-4 carbon atoms such as, for example, the methyl, ethyl, propyl, 1-methylethyl, 1-methylpropyl, 2-methylpropyl or 1,1-dimethylethyl radical, the term "(C₁ -C₈)-alkyl" is to be understood as meaning the abovementioned alkyl radicals and, for example, the pentyl, 2-methylbutyl or 1,1-dimethylpropyl radical, the hexyl, heptyl, octyl radical, or 1,1,3,3-tetramethylbutyl; the term "(C₁ -C₁₂)-alkyl" is to be understood as meaning the abovementioned alkyl radicals as well as, for example, the nonyl, decyl, undecyl or dodecyl radical; the term "(C₃ -C₈)-cycloalkyl" is to be understood as meaning the cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl group; the term "(C₁ -C₄)-alkoxy" is to be understood as meaning an alkoxy group whose hydrocarbon radical has the meaning given for the term "(C₁ -C₄)-alkyl"; the term "(C₃ -C₈)-cycloalkoxy" is to be understood as meaning a cycloalkoxy group whose hydrocarbon radical has the meaning given under "(C₃ -C₈)-cycloalkyl"; the term "(C₁ -C₄)-alkylthio" is to be understood as meaning an alkylthio group whose hydrocarbon radical has the meaning given for the term "(C₁ -C₄)-alkyl"; the term "(C₁ -C₄)-haloalkoxy" is to be understood as meaning a haloalkoxy group whose halohydrocarbon radical has the meaning given for the term "(C₁ -C₄)-haloalkyl", the term "(C₁ -C₄)-alkoxy-(C₁ -C₄)-alkyl" is to be understood as meaning, for example, a 1-methoxyethyl group, a 2-methoxyethyl group, a 2-ethoxyethyl group, a methoxymethyl or ethoxymethyl group, a 3-methoxypropyl group or a 4-butoxybutyl group; the term "(C₁ -C₄)-alkylthio-(C₁ -C₄)-alkyl" is to be understood as meaning, for example, methylthiomethyl, ethylthiomethyl, propylthiomethyl, 2-methylthioethyl, 2-ethylthioethyl or 3-methylthiopropyl; the term "(C₁ -C₄)-alkylamino" is to be understood as meaning an alkylamino group whose hydrocarbon radical has the meaning given under the term "(C₁ -C₄)-alkyl", preferably the ethyl and methylamino group; the term "di-(C₁ -C₄)-alkylamino" is to be understood as meaning a dialkylamino group whose hydrocarbon radicals have the meaning given under the term "(C₁ -C₄)-alkyl", preferably the dimethyl and diethylamino group; the term "(C₁ -C₄)-haloalkyl" is to be understood as meaning an alkyl group mentioned under the term "(C₁ -C₄)-alkyl", in which one or more hydrogen atoms is replaced by the abovementioned halogen atoms, preferably chlorine or fluorine, such as, for example, the trifluoromethyl group, the 2,2,2-trifluoroethyl group, the chloromethyl or the fluoromethyl group, the difluoromethyl group or the 1,1,2,2-tetrafluoroethyl group; the term (C₃ -C₈)-cycloalkyl-(C₂ -C₄)-alkyl"is to be understood as meaning one of the abovementioned (C₁ -C₄)-alkyl groups which is substituted by one of the abovementioned (C₃ -C₄)-cycloalkyl groups, for example cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl or 1-cyclohexyl-1-methyl-ethyl; the term "phenyl-(C₁ -C₄)-alkyl" is to be understood as meaning one of the abovementioned (C₁ -C₄)-alkyl groups which is substituted by a phenyl group, for example the benzyl group, the 2-phenylethyl group, the 1-phenylethyl group, the 1-methyl-1-phenylethyl group, the 3-phenylpropyl group, the 4-phenylbutyl group or the 2-methyl-2-phenylethyl group; the term "aryl" is to be understood as meaning, for example, phenyl, naphthyl or biphenylyl, preferably phenyl; the term "heteroaryl" is to be understood as meaning an aryl radical in which at least one CH group is replaced by N and/or at least two adjacent CH groups are replaced by S, NH or O; the term "benzyloxy-(C₁ -C₄)-alkyl" is to be understood as meaning a (C₁ -C₄)-alkyl group which has the abovementioned meanings and which is substituted by a benzyloxy group, for example the benzyloxymethyl or the 2-(benzyloxy)-ethyl group; the term "(C₃ -C₈)-cycloalkyl-(C₁ -C₄)-alkoxy" is to be understood as meaning a (C₁ -C₄)-alkoxy group which has the abovementioned meanings and which is substituted by a (C₃ -C₈)-cycloalkyl group which has the abovementioned meanings, for example the cyclopropylmethyl or the cyclohexylmethyl group; the term "tri-(C₁ -C₈)-alkylsilyl" is to be understood as meaning a trialkylsilyl group which carries preferably two methyl groups and one (C₁ -C₈)-alkyl group having the abovementioned meanings, for example the trimethylsilyl, the dimethylethylsilyl or the dimethyloctylsilyl group; the term "di-(C₁ -C₈)-alkyl-(C₁ -C₄)-haloalkylsilyl" is to be understood as meaning a silyl radical which carries preferably two methyl groups and one (C₁ -C₄)-haloalkyl radical having the meanings given under the term (C₁ -C₄)-haloalkyl, for example the dimethyl-3,3,3-trifluoropropylsilyl radical; the term "(C₁ -C₄)-alkoxy-(C₁ -C₄)-alkoxy" is to be understood as meaning, for example, the ethoxymethoxy, 2-ethoxyethoxy, 2-butoxyethoxy or 2-methoxyethoxy group; the term "(C₂ -C₈)-alkenyl" is to be understood as meaning, for example, the allyl, 1-methylallyl, 2-butenyl or 3-methyl-2-butenyl group; the term "(C₂ -C₈)-alkynyl" is to be understood as meaning, for example, the propargyl, 2-butynyl or 2-pentynyl group; the term "tri-(C₁ -C₄)-alkylsilylmethoxy" is to be understood as meaning a trialkylsilylmethoxy radical which has preferably 2 methyl groups and in which the (C₁ -C₄)-alkyl group has the abovementioned meanings; and the term "di-(C₁ -C₈)-alkyl-phenyl-(C₁ -C₄)-alkylsilyl" is to be understood as meaning a trialkylsilyl radical which has preferably two methyl groups and in which one alkyl group has the meanings mentioned above for the term "phenyl-(C₁ -C₄)-alkyl", preferably the dimethylbenzylsilyl group.

What has been explained above applies correspondingly to homologues or radicals derived thereof.

The present invention relates to the compounds of the formula I in the form of the free base or of an acid addition salt. Acids which can be used for salt formation are inorganic acids such as hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid, phosphoric acid, or organic acids such as formic acid, acetic acid, propionic acid, malonic acid, oxalic acid, fumaric acid, adipic acid, stearic acid, oleic acid, methanesulfonic acid, benzenesulfonic acid or toluenesulfonic acid.

Some of the compounds of the formula I have one or more asymmetric carbon atoms. Racemates and diastereomers can therefore occur. The invention embraces the pure isomers as well as their mixtures. The diastereomer mixtures can be resolved into the components by customary methods, for example by selective crystallization from suitable solvents or by chromatography. Racemates can be resolved to give the enantiomers by conventional methods, for example by salt formation with an optically active acid, separation of the diasteromeric salts and liberation of the pure enantiomers by means of a base.

If Q¹ is a cycloalkyl group of the formula II and n is 4, 5 or 6, preferably 5, then E and a radical R⁴ or R⁵ which is preferably in the 4-position if n=5 are preferably in the cis-configuration relative to each other.

The invention furthermore relates to a process for the preparation of compounds of the formula I, which comprises reacting a compound of the formula IV ##STR6## in which R¹, R² and R³ are as defined in formula I and Z is a leaving group, for example halogen, alkylthio, alkanesulfonyloxy or arylsulfonyloxy, alkylsulfonyl or arylsulfonyl, with a nucleophile of the formula V

    HX--E--Q                                                   (V)

in which X, E and Q are as defined in formula I and, if R³ is hydrogen, the resulting compounds of the formula I are optionally chlorinated or brominated on carbon atom 5 of the pyrimidine.

The above-described substitution reaction is known in principle. The leaving group Z can be varied within wide limits and can be, for example, a halogen atom such as fluorine, chlorine, bromine or iodine, or alkylthio such as methyl- or ethylthio, or alkanesulfonyloxy such as methane-, trifluoromethane- or ethanesulfonyloxy, or arylsulfonyloxy such as benxenesulfonyloxy or toluenesulfonyloxy, or alkylsulfonyl such as methyl- or ethylsulfonyl, or arylsulfonyl such as phenyl- or toluenesulfonyl.

The abovementioned reaction is carried out in a temperature range of 20°-150° C., expediently in the presence of a base and if appropriate in an inert organic solvent such as N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, N-methylpyrrolidin-2-one, dioxane, tetrahydrofuran, 4-methyl-2-pentanone, methanol, ethanol, butanol, ethylene glycol, ethylene glycol dimethyl ether, toluene, chlorobenzene or xylene. Mixtures of the solvents mentioned can also be used.

In the event that X is oxygen, then suitable bases are, for example, carbonates, hydrogen carbonates, amides or hydrides of alkali metals or alkaline earth metals such as sodium carbonate, sodium hydrogen carbonate, potassium carbonate, sodium amide or sodium hydride, and in the event that X is NH, they are, for example, carbonates, hydrogen carbonates, hydroxides, amides or hydrides of alkali metals or alkaline earth metals such as sodium carbonate, sodium hydrogen carbonate, potassium carbonate, sodium hydroxide, sodium amide or sodium hydride, or organic bases such as triethylamine or pyridine. A second equivalent of an amine V can also be used as auxiliary base.

The starting compounds of the formula IV can be prepared by processes which are analogous to known processes. The starting materials used are acetoacetic ester derivatives which are converted into the halopyrimidines via the corresponding hydroxypyrimidines: ##STR7##

Furthermore, the starting compounds of the formula IV can be obtained from malonic ester derivatives in analogy to known processes: ##STR8##

In the event that X is oxygen, the nucleophiles of the formula V, which are required as starting materials, can be prepared by known processes, for example by reducing a carbonyl group with a suitable reducing agent, for example a complex metal hydride or, in the case of an aldehyde or ketone, also using hydrogen and a hydrogenation catalyst. Other possibilities are the reaction of an organometal compound with a carbonyl group or an oxirane. To synthesize cyclohexanol derivatives, it is also possible to react suitable substituted phenols with hydrogen in the presence of a hydrogenation catalyst.

In the event that X is NH, the nucleophiles of the formula V, which are required as starting materials, can also be prepared by known methods, for example reduction of an oxime or of a nitrile with a suitable reducing agent, for example a complex metal hydride or hydrogen in the presence of a hydrogenation catalyst, reductive amination or Leuckart-Wallach reaction of an aldehyde or ketone or Gabriel reaction of an alkyl halide or alkyl tosylate. To synthesize cyclohexylamine derivatives, it is also possible to react suitable substituted anilines with hydrogen in the presence of a hydrogenation catalyst.

The compounds of the formula I in which R³ is halogen can be halogenated by known processes. ##STR9##

In the case of the 5-chloro derivatives, substances which can be used are, for example, elemental chlorine, sodium hypochlorite, sulfuryl chloride or N-chlorosuccinimide, and particularly suitable for the bromination are elemental bromine or N-bromosuccinimide. Examples of suitable solvents are dichloromethane, chloroform or glacial acetic acid.

The active ingredients are suitable for controlling animal pests, in particular insects, arachnids, helminths and molluscs, very particularly preferably for controlling insects and arachnids, which can be found in agriculture, in livestock breeding, in forests, in the protection of stored goods and materials as well as in the field of hygiene, and they are well tolerated by plants and have a favorable toxicity to warm-blooded species. They are active against normally-sensitive and resistant species and against all or some stages of development. The abovementioned pests include:

From the order of the Acarina, for example Acarus siro, Agras spp., Ornithodoros spp., Dermanyssus gallinae, Eriophyes ribis, Phyllocoptruta oleivora, Boophilus spp., Rhipicephalus spp., Amblyomma spp., Hyalomma spp., Ixodes spp., Psoroptes spp., Chorioptes spp., Sarcoptes spp., Tarsonemus spp., Bryobia praetiosa, Panonychus spp., Tetranychus spp., Eotetranychus spp., Oligonychus spp., Eutetranychus spp.

From the order of the Isopoda, for example, Oniscus asellus, Armadillidium vulgare and Porcellio scaber.

From the order of the Diplopoda, for example, Blaniulus guttulatus.

From the order of the Chilopoda, for example, Geophilus carpophagus and Scutigera spp.

From the order of the Symphyla, for example, Scutigerella immaculata.

From the order of the Thysanura, for example, Lepisma saccharina.

From the order of the Collembola, for example, Onychiurus armatus.

From the order of the Orthoptera, for example, Blatta orientalis, Periplaneta americana, Leucophaea maderae, Blattella germanica, Acheta domesticus, Gryllotalpa spp., Locusta migratoria migratorioides, Melanoplus differentialis and Schistocerca gregaria.

From the order of the Isoptera, for example, Reticulitermes spp.

From the order of the Anoplura, for example, Phylloxera vastatrix, Pemphigus spp., Pediculus humanus corporis, Haematopinus spp. and Linognathus spp.

From the order of the Mallophaga, for example, Trichodectes spp. and Damalinea spp.

From the order of the Thysanoptera, for example, Hercinothrips femoralis and Thrips tabaci.

From the order of the Heteroptera, for example, Eurygaster spp., Dysdercus intermedius, Piesma quadrata, Cimex lectularius, Rhodnius prolixus and Triatoma spp.

From the order of the Homoptera, for example, Aleurodes brassicae, Bemisia tabaci, Trialeurodes vaporariorum, Aphis gossypii, Brevicoryne brassicae, Cryptomyzus ribis, Doralis fabae, Doralis pomi, Eriosoma lanigerum, Hyalopterus arundinis, Macrosiphum avenae, Myzus spp., Phorodon humuli, Rhopalosiphum padi, Empoasca spp., Euscelus bilobatus, Nephotettix cincticeps, Lecanium corni, Saissetia oleae, Laodelphax striatellus, Nilaparvata lugens, Aonidiella aurantii, Aspidiotus hederae, Pseudococcus spp. and Psylla spp.

From the order of the Lepidoptera, for example, Pectinophora gossypiella, Bupalus piniarius, Cheimatobia brumata, Lithocolletis blancardella, Hyponomeuta padella, Plutella maculipennis, Malacosoma neustria, Euproctis chrysorrhoea, Lymantria spp., Bucculatrix thurberiella, Phyllocnistis citrella, Agrotis spp., Euxoa spp., Feltia spp., Earias insulana, Heliothis spp., Laphygma exigua, Mamestra brassicae, Panolis flammea, Prodenia litura, Spodoptera spp., Trichoplusia ni, Carpocapsa pomonella, Pieris spp., Chilo spp., Pyrausta nubilalis, Ephestia kuehniella, Galleria mellonella, Cacoecia podana, Capua reticulana, Choristoneura fumiferana, Clysia ambiguella, Homona magnanima and Tortrix viridana.

From the order of the Coleoptera, for example, Anobium punctatum, Rhizopertha dominica, Bruchidius obtectus, Acanthoscelides obtectus, Hylotrupes bajulus, Agelastica alni, Leptinotarsa decemlineata, Phaedon cochleariae, Diabrotica spp., Psylloides chrysocephala, Epilachna varivestis, Atomaria spp., Oryzaephilus surinamensis, Anthonomus spp., Sitophilus spp., Otiorrhynchus sulcatus, Cosmopolites sordidus, Ceuthorrhynchus assimilis, Hypera postica, Dermestes spp., Trogoderma spp., Anthrenus spp., Attagenus spp., Lyctus spp., Meligethes aeneus, Ptinus spp., Niptus hololeucus, Gibbium psylloides, Tribolium spp., Tenebrio molitor, Agriotes spp., Conoderus spp., Melolontha melolontha, Amphimallon solstitialis and Costelytra zealandica.

From the order of the Hymenoptera, for example, Diprion spp., Hoplocampa spp., Lasius spp., Monomorium pharaonis and Vespa spp.

From the order of the Diptera, for example, Aedes spp., Anopheles spp., Culex spp., Drosophila melanogaster, Musca spp., Fannia spp., Calliphora erythrocephala, Lucilia spp., Chrysomyia spp., Cuterebra spp., Gastrophilus spp., Hypobosca spp., Stomoxys spp., Oestrus spp., Hypoderma spp., Tabanus spp., Tannia spp., Bibio hortulanus, Oscinella frit, Phorbia spp., Pegomyia hyoscyami, Ceratitis capitata, Dacus oleae and Tipula paludosa.

From the order of the Siphonaptera, for example, Xenopsylla cheopis and Ceratophyllus spp.

From the order of the Arachnida, for example, Scorpio maurus and Latrodectus mactans.

From the class of the Helminthes, for example, Haemonchus, Trichostrongulus, Ostertagia, Cooperia, Chabertia, Strongyloides, Oesophagostomum, Hyostrongulus, Ancylostoma, Ascaris and Heterakis as well as Fasciola and phytopathogenic nematodes, for example those from the genera Meloidogyne, Heterodera, Ditylenchus, Aphelenchoides, Radopholus, Globodera, Pratylenchus, Longidorus and Xiphinema.

From the class of the Gastropoda, for example, Deroceras spp., Arion spp., Lymnaea spp., Galba spp., Succinea spp., Biomphalaria spp., Bulinus spp. and Oncomelania spp. From the class of the Bivalva, for example, Dreissena spp.

The invention also relates to insecticidal and acaricidal agents which contain the compounds of the formula I, besides suitable formulation auxiliaries.

The agents according to the invention generally contain the active substances of the formula I to the extent of 1 to 95% by weight.

They can be formulated in various ways, depending on the prevailing biological and/or chemico-physical parameters. The following are therefore possible for formulation: wettable powders (WP), emulsifiable concentrates (EC), aqueous solutions (SC), emulsions, sprayable solutions, dispersions on an oil or water basis (SC), suspoemulsions (SC), dusts (DP), seed-dressing agents, granules in the form of microgranules, spray granules, coated granules and adsorption granules, water-dispersible granules (WG), ULV formulations, microcapsules, waxes or baits.

These individual formulation types are known in principle and are described, for example, in:

Winnacker-Kuchler, "Chemische Technologie" [Chemical Technology], Volume 7, C. Hauser Verlag Munich, 4th Ed. 1986; van Falkenberg, "Pesticides Formulations", Marcel Dekker N.Y., 2nd Ed. 1972-73; K. Martens, "Spray Drying Handbook" 3rd Ed 1979, G. Goodwin Ltd. London.

The formulation auxiliaries which are required, such as inert materials, surfactants, solvents and other additives are equally known and are described, for example, in: Watkins, "Handbook of Insecticide Dust Diluents and Carriers" 2nd Ed, Darland Books, Caldwell N.J.; H.v. Olphen, "Introduction to Clay Colloid Chemistry", 2nd Ed., J. Wiley & Sons, N.Y.; Marschen, "Solvents Guide", 2nd Ed., Interscience, N.Y. 1950; McCutcheon's, "Detergents and Emulsifiers Annual" MC Publ Corp., Ridgewood N.J.; Sisley and Wood, "Encyclopedia of Surface Active Agents", Chem. Publ. Co. Inc., N.Y. 1964; Schonfeldt, "Grenzflachenaktive Athylenoxidaddukte" [Surface-active Ethylene Oxide Adducts], Wiss. Verlagsgesell., Stuttgart 1976; Winnacker-Kuchler, "Chemische Technologie" [Chemical Technology], Volume 7, C. Hauser Verlag Munich, 4th Ed. 1986.

Based on these formulations, it is also possible to produce combinations with other pesticidally active substances, fertilizers and/or growth regulators, for example in the form of a readymix or a tank mix. Wettable powders are preparations which are uniformly dispersible in water and which contain, besides the active substance and in addition to a diluent or inert material, wetting agents, for example polyoxethylated alkylphenols, polyoxethylated fatty alcohols, alkyl- or alkylphenolsulfonates, and dispersing agents, for example sodium ligninsulfonate, sodium 2,2'-dinaphthylmethane-6,6'-disulfonate, sodium dibutylnaphthalenesulfonate, or sodium oleylmethyltaurate.

Emulsifiable concentrates are prepared by dissolving the active substance in an organic solvent, for example butanol, cyclohexanone, dimethylformamide, xylene or higher-boiling aromatics or hydrocarbons, with addition of one or more emulsifiers. Examples of emulsifiers which can be used are: calcium salts of alkylarylsulfonates, such as calcium dodecylbenzenesulfonate, or nonionic emulsifiers such as fatty acid polyglycol esters, alkylaryl polyglycol ethers, fatty alcohol polyglycol ethers, propylene oxide/ethylene oxide condensation products, alkyl polyethers, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters or polyoxethylene sorbitol esters.

Dusts are obtained by grinding the active substance with finely divided solid substances, for example talc, natural clays such as kaolin, bentonite, pyrophyllite or diatomaceous earth. Granules can be prepared either by atomizing the active substance onto adsorptive, granulated inert material or by applying active substance concentrates onto the surface of carrier materials such as sand or kaolinites, or of granulated inert material, by means of adhesives, for example polyvinyl alcohol or sodium polyacrylate, or alternatively mineral oils. Suitable active substances can also be granulated in the fashion conventional for the preparation of fertilizer granules, if desired as a mixture with fertilizers.

The active substance concentration in wettable powders is, for example, approximately 10 to 90% by weight, the remainder to 100% is composed of conventional formulation components. In the case of emulsifiable concentrates, the active substance concentration can be approximately 5 to 80% by weight. Formulations in the form of dusts usually contain 5 to 20% of active substance, sprayable solutions approximately 2 to 20% by weight. In the case of granules, the active substance content depends partly on whether the active compound is liquid or solid and on which granulation auxiliaries, fillers, etc. are used.

In addition, the active substance formulations mentioned contain, if appropriate, the adhesives, wetting agents, dispersants, emulsifiers, penetrants, solvents, fillers or carriers which are conventional in each case.

For use, the concentrates which exist in commercially available form are, if appropriate, diluted in the customary manner, for example using water in the case of wettable powders, emulsifiable concentrates, dispersions and also in the case of some microgranules. Preparations in the form of a dust and granulated preparations as well as sprayable solutions are customarily not further diluted with other inert substances before use.

The application rate required depends on the external conditions such as, inter alia, temperature and humidity. It can vary within wide limits, for example between 0.001 and 10.0 kg/ha or more of active ingredient, but it is preferably between 0.005 and 5 kg/ha.

The active substances according to the invention may be present in their commercially available formulations and in the application forms prepared from these formulations in the form of mixtures with other active substances such as insecticides, attractants, sterilants, acaricides, nematicides, fungicides, growth-regulating substances or herbicides.

The pesticides include, for example, phosphoric esters, carbamates, carboxylic esters, formamidines, tin compounds and substances produced by microorganisms.

Preferred components for mixtures are

1. from the group comprising the phosphorus compounds acephate, azamethiphos, azinphos-ethyl, azinphosmethyl, bromophos, bromophos-ethyl, chlorfenvinphos, chlormephos, chlorpyrifos, chlorpyriphos-methyl, demeton, demeton-S-methyl, demeton-S-methyl-sulphone, dialifos, diazinon, dichlorvos, dicrotophos, O,O-1,2,2,2-tetrachloroethyl phosphorothioate (SD 208 304), dimethoate, disulfoton, EPN, ethion, ethoprophos, etrimfos, famphur, fenamiphos, fenitrothion, fensulfothion, fenthion, fonofos, formothion, heptenophos, isazophos, isothioate, isoxathion, malathion, methacrifos, methamidophos, methidathion, salithion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosfolan, phosmet, phosphamidon, phoxim, pirimiphos-ethyl, pirimiphosmethyl, profenofos, propaphos, proetamphos, prothiolos, pyraclofos, pyridapenthion, quinalphos, sulprofos, temephos, terbufos, tetraclorvinphos, thiometon, triazophos, trichlorphon, vamidothion;

2. from the group comprising the carbamates aldicarb, 2-secbutylphenyl methylcarbamate (BPMC), carbaryl, carbofuran, carbosulfan, cloethocarb, ethiofencarb, furathiocarb, isoprocarb, methomyl, 5-methyl-m-cumenylbutyryl (methyl)carbamate, oxamyl, pirimicarb, propoxur, thiodicarb, thiofanox, ethyl 4,6,9-triaza-4-benzyl-6,10-dimethyl-8-oxa-7-oxo-5,11-dithia-9-dodecenoate (OK 135), 1-methylthio-(ethylidenamino)-N-methyl-N-(morpholinothio)carbamate (UC 51717);

3. from the group comprising the carboxylic esters allethrin, alphamethrin, 5-benzyl-3-furylmethyl -(E)-(1R)-cis-2,2-dimethyl-3-(2-oxothiolan-3-ylidenemethyl)cyclopropanecarboxylate, bioallethrin, bioallethrin ((S)cyclopentyl isomer), bioresmethrin, biphenate, (RS)-1-cyano-1-(6-phenoxy-2-pyridyl)methyl -(1RS)-trans-3-(4-tert.butylphenyl)-2,2-dimethylcyclopropanecarboxylate (NCI 85193), cycloprothrin, cyhalothrin, cypermethrin, cyphenothrin, deltamethrin, empenthrin, esfenvalerate, fenfluthrin, fenpropathrin, fenvalerate, flucythrinate, flumethrin, fluvalinate (D isomer), permethrin, pheothrin ((R) isomer), d-pralethrin, pyrethrins (natural products), resmethrin, tefluthrin, tetramethrin, tralomethrin;

4. from the group comprising the amidines amitraz, chlordimeform;

5. from the group comprising the tin compounds cyhexatin, fenbutatin oxide;

6. others abamectin, Bacillus thuringiensis, bensultap, binapacryl, bromopropylate, buprofezin, camphechlor, cartap, chlorobenzilate, chlorfluazuron, 2-(4-chlorophenyl) -4,5-diphenylthiophene (UBI-T 930), chlorfentezine, 2-naphthylmethyl cyclopropanecarboxylate (Ro12-0470), cyromazin, ethyl N-(3,5-dichloro -4-(1,1,2,3,3,3-hexafluoro-1-propyloxy)phenyl) carbamoyl)-2-chlorobenzcarboximidate, DDT, dicofol, N-(N(3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)-phenylamino)carbonyl) -2,6-difluorobenzamide(XRD473), diflubenzuron, N-(2,3-dihydro-3-methyl-1,3-thiazol -2-ylidene)-2,4-xylidine, dinobuton, dinocap, endosulfan, ethofenprox, (4-ethoxyphenyl)(dimethyl)(3-(3-phenoxyphenyl)propyl)silane, (4-ethoxyphenyl)(3(4-fluoro-3-phenoxyphenyl)propyl)dimethylsilane, fenoxycarb, 2-fluoro-5-(4-(4-ethoxyphenyl)-4-methyl-1-pentyl)diphenyl ether (MTI 800) granulosis and nuclear polyhedrosis viruses, fenthiocarb, flubenzimine, flucycloxuron, flufenoxuron, gamma-HCH, hexythiazox, hydramechylnon (AC 217300), ivermectin, 2-nitromethyl-4,5-dihydro-6H-thiazine (SD 52618), 2-nitromethyl-3,4-dihydrothiazole (SD 35651), 2-nitro-methylene-1,2-thiazinan-3-ylcarbamaldehyde (WL 108477), propargite, teflubenzuron, tetradifon, tetrasul, thiocyclam and triflumuron.

The active substance content of the use forms prepared from the commercially available formulations can be from 0.00000001 to 95% by weight of active substance, preferably between 0.00001 and 1% by weight.

Application is effected in a conventional fashion, matched to the use forms.

The active substances according to the invention are also suitable for controlling endo- and ectoparasites in the field of veterinary medicine or in the field of animal husbandry.

The active substances according to the invention are applied in a known fashion, such as by oral administration in the form of, for example, tablets, capsules, potions or granules, by dermal administration in the form of, for example, dipping, spraying, pouring-on and spotting-on and powdering, and also by parenteral administration in the form of, for example, an injection.

The novel compounds of the formula I according to the invention can accordingly also be employed particularly advantageously in livestock husbandry (for example cattle, sheep, pigs and poultry such as chickens, geese etc.). In a preferred embodiment of the invention, the novel compounds, if appropriate in suitable formulations (cf. above) and if appropriate with the drinking water or feed, are administered orally to the animals. Since they are excreted effectively in the feces, the development of insects in the feces of the animals can be prevented very simply in this fashion. The dosages and formulations suitable in each case are particularly dependent on the type and stage of development of the livestock and also on the infestation pressure, and can easily be determined and laid down by conventional methods. In the case of cattle, the novel compounds can be employed, for example, at dosage rates of 0.01 to 1 mg/kg of body weight.

The compounds of the formula I according to the invention are also distinguished by an outstanding fungitidal activity. Fungal pathogens which have already entered the plant tissue can be controlled successfully in a curative manner. This is particularly important and advantageous in the case of those fungal diseases which can no longer be controlled effectively with the otherwise customary fungicides once infection has taken place. The spectrum of action of the claimed compounds embraces a large number of various economically important phytopathogenic fungi such as, for example, Pyricularia oryzae, Leptosphaeria nodorum, Drechslera teres, powdery mildew species, Venturia inaequalis, Botrytis cinerea, Pseudocercosporella herpotrichoides, rusts as well as representatives of the Oomycetes such as, for example, Phytophthora infestans and Plasmopara viticola.

Besides, the compounds according to the invention are also suitable for use in industrial fields, for example as wood preservatives, as preservatives in paints, in cooling lubricants for metalworking, or as preservatives in drilling and cutting oils.

The invention also relates to agents which comprise the compounds of the formula I besides suitable formulation auxiliaries. The agents according to the invention generally comprise 1 to 95% by weight of the active substances of the formula I.

They can be formulated in various ways, depending on the prevailing biological and/or chemico-physical parameters. The following possibilities are therefore suitable for formulation: wettable powders (WP), emulsifiable concentrates (EC), aqueous dispersions on oil or water basis (SC), suspoemulsions (SC), dusts (DP), seed-dressing agents, granules in the form of water-dispersible granules (WG), ULV formulations, microcapsules, waxes or baits.

These individual formulation types are known in principle and are described, for example, in: Winnacker-Kuchler, "Chemische Technologie" [Chemical Technology], Volume 7, C. Hauser Verlag Munich, 4th Ed. 1986; van Falkenberg, "Pesticides Formulations", Marcel Dekker N.Y., 2nd Ed. 1972-73; K. Martens, "Spray Drying Handbook" 3rd Ed. 1979, G Goodwin Ltd London.

The formulation auxiliaries which are required, such as inert materials, surfactants, solvents and other additives are equally known and are described, for example, in: Watkins, "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Darland Books, Caldwell N.J.; H.v.Olphen, "Introduction to Clay Colloid Chemistry", 2nd Ed., J. Wiley & Sons, N.Y.; Marschen, "Solvents Guide" 2nd Ed., Interscience, N Y 1950; McCutcheon's, "Detergents and Emulsifiers Annual" MC Publ Corp , Ridgewood N.J.; Sisley and Wood, "Encyclopedia of Surface Active Agents", Chem. Publ. Co. Inc., N.Y. 1964; Schonfeldt, "Grenzflachenaktive Athylenoxidaddukte" [Surface-active Ethylene Oxide Adducts], Wiss. Verlagsgesell., Stuttgart 1976; Winnacker-Kuchler, "Chemische Technologie" [Chemical Technology], Volume 7, C. Hauser Verlag Munich, 4th Ed. 1986.

The active substances according to the invention can be employed, in their commercially available formulations, either on their own or in the form of a combination with other fungicides known from the literature.

Fungicides which are known from the literature and which can be combined according to the invention with the compounds of the formula (I) are, for example, the following products:

anilazine, benalaxyl, benodanil, benomyl, binapacryl, bitertanol, buthiobat, captafol, captan, carbendazim, carboxin, CGD-94240 F, chlobenzthiazone, chlorthalonil, cymoxanil, cyproconazole, cyprofuram, dichlofluanid, dichlomezin, diclobutrazol, diethofencarb, difluconazole, dimethirimol, dimethomorph, diniconazole, dinocap, dithianon, dodemorph, dodine, edifenfos, ethirimol, etridazole, fenarimol, fenfuram, fenpiclonil, fenpropidin, fenpropimorph, fentin acetate, fentin hydroxide, fluaziram, fluobenzimine, fluorimide, flusilazole, flutolanil, flutriafol, folpet, fosetyl-aluminum, fuberidazole, furalaxyl, furmecyclox, guazatine, hexaconazole, imazalil, iprobenfos, iprodione, isoprothiolane, copper compounds such as copper oxychloride, copper oxine, copper oxide, mancozeb, maneb, mepronil, metalaxyl, methasulfocarb, methfuroxam, myclobutanil, nabam, nitrothalidopropyl, nuarimol, ofurace, oxadixyl, oxycarboxin, penconazole, pencycuron, PP 969, probenazole, probinel, prochloraz, procymidon, propamocarb, propiconazole, prothiocarb, pyracarbolid, pyrifenox, pyroquilon, rabenzazole, sulfur, tebuconazole, thiabendazole, thiofanate-methyl, thiram, tolclofos-methyl, tolylfluanid, triadimefon, triadimenol, tricyclazole, tridemorph, triflumizol, triforine, vinchlozolin, zineb, sodium dodecylsulfonate, sodium dodecylsulfate, sodium C13/C15-alcohol ether sulfonate, sodium cetostearylphosphate, dioctyl sodium sulfosuccinate, sodium isopropylnaphthalenesulfonate, sodium methylenebisnaphthalenesulfonate, cetyltrimethylammonium chloride, salts of long-chain primary, secondary or tertiary amines, alkylpropylenamines, laurylpyrimidinium-bromide, ethoxylated quaternized fatty amines, alkyldimethylbenzylammonium chloride and 1-hydroxyethyl-2-alkylimidazoline.

The abovementioned components for the combinations represent known active substances, most of which are described in GH.R Worthing, U.S.B. Walker, The Pesticide Manual, 7th Edition (1983), British Crop Protection Council.

The active substance content of the use forms prepared from the commercially available formulations can vary within wide ranges, the active substance concentration of the use forms can be between 0.0001 and 95% by weight of active substance, preferably between 0.001 and 1% by weight. They are used in a fashion matched to the use forms.

The following examples serve to illustrate the invention.

A. Formulation Examples

a) A dust is obtained by mixing 10 parts by weight of active substance and 90 parts by weight of talc as inert material and comminuting the mixture in a hammer mill.

b) A wettable powder which is readily dispersible in water is obtained by mixing 25 parts by weight of active substance, 65 parts by weight of kaolin-containing quartz as inert material, 10 parts by weight of potassium ligninsulfonate and 1 part by weight of sodium oleoylmethyltaurate as wetting and dispersing agent, and grinding the mixture in a pin-disk mill.

c) A dispersion concentrate which is readily dispersible in water is prepared by mixing 40 parts by weight of active substance with 7 parts by weight of a sulfosuccinic monoester, 2 parts by weight of a sodium ligninsulfonate and 51 parts by weight of water and grinding the mixture in a ball mill to a fineness of below 5 microns.

d) An emulsifiable concentrate can be prepared from 15 parts by weight of active substance, 75 parts by weight of cyclohexanone as solvent and 10 parts by weight of oxethylated nonylphenol (10 EO) as emulsifier.

e) Granules can be prepared from 2 to 15 parts by weight of active substance and an inert granulate carrier material such as attapulgite, granulated pumice and/or quartz sand. It is expedient to use a suspension of the wettable powder of Example b) with a solids content of 30%, which is sprayed onto the surface of attapulgite granules, and these are dried and mixed intimately. The amount of the wettable powder is approx. 5% by weight and that of the inert carrier material approx. 95% by weight of the finished granules.

B. Biological Examples (use as fungicide)

EXAMPLE 1

Barley plants in the 3-leaf stage are heavily inoculated with conidia of powdery mildew of barley (Erysiphe graminis f. sp. hordei) and placed in a greenhouse at 20° C. and a relative atmospheric humidity of 90-95%. 24 hours after the inoculation, the plants are wetted uniformly with the compounds listed in Table 1 at the active substance concentrations which are indicated. After an incubation time of 10 days, the plants are examined for incidence of powdery mildew of barley. The disease indicence is expressed in % of diseased leaf area, relative to untreated, 100% infected control plants.

Applied at 500 mg of active substance/1 of spray mixture, the following substances are found to suppress disease completely:

Compounds according to Example No. 9, 17, 25, 30, 55, 80, 93, 99, 100.

EXAMPLE 2

Barley plants cv. "Igri" in the 2-leaf stage are treated to runoff point with an aqueous suspension of the claimed compounds.

After the spray coating has dried on, the plants are inoculated with an aqueous spore suspension of Pyrenophora teres and incubated for 16 hours in a controlled-environment cabinet at a relative atmospheric humidity of 100%. The infected plants are subsequently grown on in the greenhouse at 25° C. and a relative atmospheric humidity of 80%.

Approx. 1 week after the inoculation, the disease is evaluated and the disease incidence is scored as diseased leaf area compared with the untreated, 100% infected control.

Applied at 500 mg of active substance/1 of spray mixture, the following substances are found to suppress disease completely:

Compounds according to Example No. 2, 9, 10, 13, 14, 17, 25, 55, 80, 93, 106.

EXAMPLE 3

Wheat cv. "Jubilar" in the 2-leaf stage is treated to runoff point with aqueous suspensions of the claimed compounds.

After the spray coating has dried on, the plants are inoculated with an aqueous spore suspension of Puccinia recondita. The dripping-wet plants are placed for approx. 16 hours in a controlled-environment cabinet at 20° C. and a relative atmospheric humidity of approx. 100%. They are then grown on in a greenhouse at a temperature of 22°-25° C. and a relative atmospheric humidity of 50-70%.

After an incubation time of approx. 2 weeks, the fungus sporulates on the entire leaf area of the untreated control plants (100% infection), so that the test plants can be evaluated for disease. The disease incidence is expressed as diseased leaf area compared with the untreated, infected control plants.

Applied at 500 mg of active substance/1 of spray mixture, the following substances are found to suppress disease completely:

Compounds according to Example No. 2, 9, 12, 17, 25, 30, 80, 93, 99.

Biological Examples (use as acaricide/insecticide)

EXAMPLE 1

Field beans (Vicia faba) heavily populated with the black bean aphid (Aphis fabae) are sprayed with aqueous dilutions of wettable powder concentrates with an active substance content of 250 ppm until the stage of beginning of runoff point is reached. The mortality of the aphids is determined after 3 days. A destruction of 100% can be achieved using the compounds according to Example No. 2, 9, 13, 17, 19, 25, 30, 55, 80, 93, 99, 106, 1741, 1749, 1750.

EXAMPLE 2

Bean plants (Phaseolus v.) are heavily populated with greenhouse spider mites (Tetranychus urticae, full population) were sprayed with the aqueous dilution of a wettable powder concentrate containing 250 ppm of the active substance in question.

The mortality of the mites was checked after 7 days. A destruction of 100% was achieved using the following compounds:

Compounds according to Example No. 2, 9, 10, 17, 19, 25, 30, 55, 80, 93, 94, 99, 106, 1741.

EXAMPLE 3

Filter papers on which eggs of the large milkweed bug (Oncopeltus fasciatus) have been placed are treated with 0.5 ml portions of aqueous dilution of the test formulation. After the coating has dried on, the Petri dish is sealed, and the interior is kept at maximum atmospheric humidity. The dishes are kept at room temperature, and the oricidal and larvicidal activities are determined after 7 days. At an active substance content of 250 ppm, a mortality of 100% was obtained with the following compounds:

Compounds according to Example No. 2, 9, 10, 13, 17, 19, 25, 30, 55, 80, 93, 95, 99, 106, 312, 1741, 1749, 1750.

EXAMPLE 4

1 ml portions of the test formulation, emulsified in water, are applied uniformly to the inside of the lid and the bottom of a Petri dish and, when the coating has dried on, batches of 10 imagines of the common housefly (Musca domestica) are introduced. The dishes are sealed and then kept at room temperature, the mortality of the test animals is determined after 3 hours. At 250 ppm (based on active substance content), the following preparations show a good activity (100% mortality) against the common housefly:

Compounds according to Example No. 9, 10, 17, 18, 19, 25, 55, 80, 93, 99, 106, 1741, 1750.

EXAMPLE 5

Rice seed is placed into glass culture dishes containing cotton wool and germinated under moist conditions and, after the stem has grown to a length of approx. 8 cm, it is dipped together with the leaves into the test solution. The test solution is allowed to run off from the treated rice plants, and the plants are transferred to culture containers and populated with batches of 10 larvae (L3) of the species Nilaparvata lugens, the individual test concentrations being kept separate from each other. After the sealed culture containers have been kept at 21° C. the mortality of the cicada larvae can be determined after 4 days.

Under these test conditions, the compounds according to Example No. 9, 25, 30, 93, 99, 432 have a 100% activity at a test concentration of 250 ppm of the active ingredient.

EXAMPLE 6

Wheat seed is pregerminated for 6 hours under water and then transferred to 10 ml glass test tubes and covered with in each case 2 ml of soil. 1 ml of water is added, and the plants remain in the glass culture dishes at room temperature (21° C.) until they have grown to a height of approx. 3 cm. Diabrotica larvae of a medium stage (batches of 10 specimens) are then transferred to the dishes and placed on the soil and, after 2 hours, 1 ml of the test liquid concentration to be tested is then pipetted onto the soil surface in the dishes.

After a standing time of 5 days under laboratory conditions (21° C.), the soil, or parts of the roots, are examined for live Diabrotica larvae, and the mortality is determined.

Under the test conditions mentioned, the compounds according to Example No. 2, 17, 19, 25, 93, 99 displayed an effectiveness of up to 100% at a test concentration of 250 ppm of the active ingredient.

EXAMPLE 7

In vitro test with tropical cattle ticks (Boophilus microplus)

The following experimental set-up allowed the activity of the claimed compounds against ticks to be demonstrated:

To prepare a suitable preparation of active substance, the active substances were dissolved at a concentration of 10% (w/v) in a mixture composed of dimethylformamide (85 g), nonylphenol polyglycol ether (3 g) and oxethylated castor oil (7 g), and the resulting emulsion concentrates were diluted with water to a test concentration of 500 ppm.

Batches of ten females of the tropical tick Boophilus microplus which had sucked themselves full were immersed for five minutes in these active substance dilutions. The ticks were subsequently dried on filter paper and then attached, by their backs, to an adhesive film for the purpose of oviposition. The ticks were kept in an incubator at 28° C. and an atmospheric humidity of 90%.

As a control, female ticks were merely immersed in water. The inhibition of oviposition two weeks after the treatment was used to assess the effectiveness. 100% mean that no ticks have deposited eggs, 0% means that all ticks have deposited eggs.

In this test, a 100% inhibition of oviposition was caused by each of the compounds 10, 19, 30 and 106 at an active substance concentration of 500 ppm.

Preparation Examples

EXAMPLE A

4-(4-tert -Butylcyclohexylamino)-5-chloro-6-ethylpyrimidine ##STR10##

3.5 g (0.02 mol) of 4,5-dichloro-6-ethylpyrimidine and 7.8 g (0.05 mol) of 4-tert-butylcyclohexylamine were heated for two hours at 100° C. without solvent. After the mixture had cooled to room temperature, it was worked up using methylene chloride/water and the organic phase was dried and concentrated. The product was chromatographed on silica gel using petroleum ether/ethyl acetate 7:3 for further purification and for the separation of the cis/trans isomers.

The trans-cyclohexylamino derivative is eluted first (0.8 g of yellow oil solidifies, m. p. 94°-96°). After a mixed fraction, which was discarded, pure cis-cyclohexylamino derivative was finally obtained (3.0 g of yellow oil).

Preparation of 4-tert-butylcyclohexylamine

312 g of 4-tert-butylcyclohexanone in 500 ml of ammonia-saturated methanol were hydrogenated at 100° C. and 100 bar in the presence of 10 g of Raney nickel. The catalyst was filtered off, the mixture was concentrated, and the crude product was purified on a thin-layer evaporator (105°/0.5 mm). 303 g of colorless liquid were obtained. The product is an isomer mixture in which the cis-cyclohexylamine derivative prevails. ##STR11##

4-(cis-4-Phenyl-cyclohexyloxy)-5,6,7,8-tetrahydroquinazoline

0.5 g (16.7 mmol) of 80% NaH was added in portions to a solution of 1.85 g (105 mmol) of cis-4-phenylcyclohexanol in 30 ml of absolute THF. After this, the mixture was heated for 1 hour at 50° C., and 1.5 g (8.75 mmol) of 4-chloro-5,6,7,8-tetrahydroquinazoline, dissolved in 15 ml of absolute THF, were added dropwise. The reaction mixture was subsequently refluxed for 2 hours. After the mixture had cooled to room temperature, it was poured into saturated NH₄ Cl solution and this was extracted with ether, and the combined organic phase was dried over MgSO₄. The solvent was evaporated in vacuo, and the residue (2.7 g) was purified by flash chromatography over silica gel, using n-hexane/ethyl acetate (2:1). Concentration gave 1.5 g (50.2% of theory), colorless crystals, m.p. 109° C. ##STR12##

4-(N-Benzoyl-piperidyl-4-oxy)-5-methoxy-6-methoxymethylpyrimidine

2.9 g (14.3 mmol) of N-benzoyl-4-hydroxypiperidine (prepared by NaBH₄ -reduction of N-benzoylpiperidin-4-one) were added to a suspension of 0.66 g (22 mmol) of 80% NaH in THF. This was then heated for 1 hour at 35°-40° C., and 2.50 g (13.3 mmol) of 4-chloro-5-methoxy-6-methoxymethyl-pyrimidine were subsequently added without dilution. The reaction mixture was heated for 5 hours at 40° C., poured into a little saturated NH₄ Cl solution and extracted 5 times using ethyl acetate. The combined organic phases were dried over MgSO₄, and the residue (3.4 g) was purified by flash chromatography over silica gel using ethyl acetate. Concentration gave 0.6 g (13% of theory) of yellow oil, n_(D) ²⁰ =1.5815.

More examples can be found in Tables I-IV below.

    ______________________________________                                         Abbreviations used                                                             ______________________________________                                         T.sup.1                                                                              ##STR13##                                                                T.sup.2                                                                              ##STR14##                                                                T.sup.3                                                                              ##STR15##                                                                T.sup.4                                                                              ##STR16##                                                                T.sup.5                                                                              ##STR17##                                                                T.sup.6                                                                              ##STR18##                                                                T.sup.7                                                                              ##STR19##                                                                T.sup.8                                                                              ##STR20##                                                                T.sup.9                                                                              ##STR21##                                                                T.sup.10                                                                             ##STR22##                                                                T.sup.11                                                                             ##STR23##                                                                T.sup.12                                                                             ##STR24##                                                                T.sup.13                                                                             ##STR25##                                                                T.sup.14                                                                             ##STR26##                                                                T.sup.15                                                                             ##STR27##                                                                T.sup.16                                                                             ##STR28##                                                                T.sup.17                                                                             ##STR29##                                                                T.sup.18                                                                             ##STR30##                                                                T.sup.19                                                                             ##STR31##                                                                T.sup.20                                                                             ##STR32##                                                                T.sup.21                                                                             ##STR33##                                                                T.sup.22                                                                             ##STR34##                                                                T.sup.23                                                                             ##STR35##                                                                T.sup.24                                                                             ##STR36##                                                                T.sup.25                                                                             ##STR37##                                                                T.sup.26                                                                             ##STR38##                                                                T.sup.27                                                                             ##STR39##                                                                T.sup.28                                                                             ##STR40##                                                                T.sup.29                                                                             ##STR41##                                                                T.sup.30                                                                             ##STR42##                                                                T.sup.31                                                                             ##STR43##                                                                T.sup.32                                                                             ##STR44##                                                                T.sup.33                                                                             ##STR45##                                                                T.sup.34                                                                             ##STR46##                                                                T.sup.35                                                                             ##STR47##                                                                T.sup.36                                                                             ##STR48##                                                                T.sup.37                                                                             ##STR49##                                                                T.sup.38                                                                             ##STR50##                                                                T.sup.39                                                                             ##STR51##                                                                T.sup.40                                                                             ##STR52##                                                                T.sup.41                                                                             ##STR53##                                                                T.sup.42                                                                             ##STR54##                                                                T.sup.43                                                                             ##STR55##                                                                T.sup.44                                                                             ##STR56##                                                                T.sup.45                                                                             ##STR57##                                                                T.sup.46                                                                             ##STR58##                                                                T.sup.47                                                                             ##STR59##                                                                T.sup.48                                                                             ##STR60##                                                                T.sup.49                                                                             ##STR61##                                                                T.sup.50                                                                             ##STR62##                                                                T.sup.51                                                                             ##STR63##                                                                T.sup.52                                                                             ##STR64##                                                                T.sup.53                                                                             ##STR65##                                                                T.sup.54                                                                             ##STR66##                                                                T.sup.55                                                                             ##STR67##                                                                T.sup.56                                                                             ##STR68##                                                                T.sup.57                                                                             ##STR69##                                                                T.sup.58                                                                             ##STR70##                                                                T.sup.59                                                                             ##STR71##                                                                T.sup.60                                                                             ##STR72##                                                                T.sup.61                                                                             ##STR73##                                                                T.sup.62                                                                             ##STR74##                                                                T.sup.63                                                                             ##STR75##                                                                T.sup.64                                                                             ##STR76##                                                                T.sup.65                                                                             ##STR77##                                                                T.sup.66                                                                             ##STR78##                                                                T.sup.67                                                                             ##STR79##                                                                T.sup.68                                                                             ##STR80##                                                                T.sup.69                                                                             ##STR81##                                                                T.sup.70                                                                             ##STR82##                                                                T.sup.71                                                                             ##STR83##                                                                T.sup.72                                                                             ##STR84##                                                                T.sup.73                                                                             ##STR85##                                                                T.sup.74                                                                             ##STR86##                                                                T.sup.75                                                                             ##STR87##                                                                T.sup.76                                                                             ##STR88##                                                                T.sup.77                                                                             ##STR89##                                                                T.sup.78                                                                             ##STR90##                                                                T.sup.79                                                                             ##STR91##                                                                T.sup.80                                                                             ##STR92##                                                                T.sup.81                                                                             ##STR93##                                                                T.sup.82                                                                             ##STR94##                                                                T.sup.83                                                                             ##STR95##                                                                T.sup.84                                                                             ##STR96##                                                                T.sup.85                                                                             ##STR97##                                                                T.sup.86                                                                             ##STR98##                                                                T.sup.87                                                                             ##STR99##                                                                T.sup.88                                                                             ##STR100##                                                               T.sup.89                                                                             ##STR101##                                                               T.sup.90                                                                             ##STR102##                                                               T.sup.91                                                                             ##STR103##                                                               T.sup.92                                                                             ##STR104##                                                               T.sup.93                                                                             ##STR105##                                                               T.sup.94                                                                             ##STR106##                                                               T.sup.95                                                                             ##STR107##                                                               T.sup.96                                                                             ##STR108##                                                               T.sup.97                                                                             ##STR109##                                                               T.sup.98                                                                             ##STR110##                                                               T.sup.99                                                                             ##STR111##                                                               T.sup.100                                                                            ##STR112##                                                               T.sup.101                                                                            ##STR113##                                                               T.sup.102                                                                            ##STR114##                                                               T.sup.103                                                                            ##STR115##                                                               T.sup.104                                                                            ##STR116##                                                               T.sup.105                                                                            ##STR117##                                                               T.sup.106                                                                            ##STR118##                                                               T.sup.107                                                                            ##STR119##                                                               T.sup.108                                                                            ##STR120##                                                               T.sup.109                                                                            ##STR121##                                                               T.sup.110                                                                            ##STR122##                                                               T.sup.111                                                                            ##STR123##                                                               T.sup.112                                                                            ##STR124##                                                               T.sup.113                                                                            ##STR125##                                                               T.sup.114                                                                            ##STR126##                                                               T.sup.115                                                                            ##STR127##                                                               T.sup.116                                                                            ##STR128##                                                               T.sup.117                                                                            ##STR129##                                                               T.sup.118                                                                            ##STR130##                                                               T.sup.119                                                                            ##STR131##                                                               T.sup.120                                                                            ##STR132##                                                               T.sup.121                                                                            ##STR133##                                                               T.sup.122                                                                            ##STR134##                                                               T.sup.123                                                                            ##STR135##                                                               T.sup.124                                                                            ##STR136##                                                               T.sup.125                                                                            ##STR137##                                                               T.sup.126                                                                            ##STR138##                                                               T.sup.127                                                                            ##STR139##                                                               T.sup.128                                                                            ##STR140##                                                               T.sup.129                                                                            ##STR141##                                                               T.sup.130                                                                            ##STR142##                                                               T.sup.131                                                                            ##STR143##                                                               T.sup.132                                                                            ##STR144##                                                               T.sup.133                                                                            ##STR145##                                                               T.sup.134                                                                            ##STR146##                                                               T.sup.135                                                                            ##STR147##                                                               T.sup.136                                                                            ##STR148##                                                               T.sup.137                                                                            ##STR149##                                                               T.sup.138                                                                            ##STR150##                                                               T.sup.139                                                                            ##STR151##                                                               T.sup.140                                                                            ##STR152##                                                               T.sup.141                                                                            ##STR153##                                                               T.sup.142                                                                            ##STR154##                                                               T.sup.143                                                                            ##STR155##                                                               T.sup.144                                                                            ##STR156##                                                               T.sup.145                                                                            ##STR157##                                                               T.sup.146                                                                            ##STR158##                                                               T.sup.147                                                                            ##STR159##                                                               T.sup.148                                                                            ##STR160##                                                               T.sup.149                                                                            ##STR161##                                                               T.sup.150                                                                            ##STR162##                                                               T.sup.151                                                                            ##STR163##                                                               T.sup.152                                                                            ##STR164##                                                               T.sup.153                                                                            ##STR165##                                                               T.sup.154                                                                            ##STR166##                                                               T.sup.155                                                                            ##STR167##                                                               T.sup.156                                                                            ##STR168##                                                               T.sup.157                                                                            ##STR169##                                                               T.sup.158                                                                            ##STR170##                                                               T.sup.159                                                                            ##STR171##                                                               T.sup.160                                                                            ##STR172##                                                               T.sup.161                                                                            ##STR173##                                                               T.sup.162                                                                            ##STR174##                                                               T.sup.163                                                                            ##STR175##                                                               T.sup.164                                                                            ##STR176##                                                               T.sup.165                                                                            ##STR177##                                                               T.sup.166                                                                            ##STR178##                                                               T.sup.167                                                                            ##STR179##                                                               T.sup.168                                                                            ##STR180##                                                               T.sup.169                                                                            ##STR181##                                                               T.sup.170                                                                            ##STR182##                                                               T.sup.171                                                                            ##STR183##                                                               T.sup.172                                                                            ##STR184##                                                               T.sup.173                                                                            ##STR185##                                                               T.sup.174                                                                            ##STR186##                                                               T.sup.175                                                                            ##STR187##                                                               T.sup.176                                                                            ##STR188##                                                               T.sup.177                                                                            ##STR189##                                                               T.sup.178                                                                            ##STR190##                                                               T.sup.179                                                                            ##STR191##                                                               T.sup.180                                                                            ##STR192##                                                               T.sup.181                                                                            ##STR193##                                                               T.sup.182                                                                            ##STR194##                                                               T.sup.183                                                                            ##STR195##                                                               T.sup.184                                                                            ##STR196##                                                               T.sup.185                                                                            ##STR197##                                                               T.sup.186                                                                            ##STR198##                                                               T.sup.187                                                                            ##STR199##                                                               T.sup.188                                                                            ##STR200##                                                               T.sup.189                                                                            ##STR201##                                                               T.sup.190                                                                            ##STR202##                                                               T.sup.191                                                                            ##STR203##                                                               T.sup.192                                                                            ##STR204##                                                               T.sup.193                                                                            ##STR205##                                                               T.sup.194                                                                            ##STR206##                                                               T.sup.195                                                                            ##STR207##                                                               T.sup.196                                                                            ##STR208##                                                               T.sup.197                                                                            ##STR209##                                                               T.sup.198                                                                            ##STR210##                                                               T.sup.199                                                                            ##STR211##                                                               T.sup.200                                                                            ##STR212##                                                               T.sup.201                                                                            ##STR213##                                                               T.sup.202                                                                            ##STR214##                                                               T.sup.203                                                                            ##STR215##                                                               T.sup.204                                                                            ##STR216##                                                               T.sup.205                                                                            ##STR217##                                                               T.sup.206                                                                            ##STR218##                                                               T.sup.207                                                                            ##STR219##                                                               T.sup.208                                                                            ##STR220##                                                               T.sup.209                                                                            ##STR221##                                                               T.sup.210                                                                            ##STR222##                                                               T.sup.211                                                                            ##STR223##                                                               T.sup.212                                                                            ##STR224##                                                               T.sup.213                                                                            ##STR225##                                                               T.sup.214                                                                            ##STR226##                                                               T.sup.215                                                                            ##STR227##                                                               T.sup.216                                                                            ##STR228##                                                               T.sup.217                                                                            ##STR229##                                                               T.sup.218                                                                            ##STR230##                                                               T.sup.219                                                                            ##STR231##                                                               T.sup.220                                                                            ##STR232##                                                               T.sup.221                                                                            ##STR233##                                                               T.sup.222                                                                            ##STR234##                                                               T.sup.223                                                                            ##STR235##                                                               T.sup.224                                                                            ##STR236##                                                               T.sup.225                                                                            ##STR237##                                                               T.sup.226                                                                            ##STR238##                                                               T.sup.227                                                                            ##STR239##                                                               T.sup.228                                                                            ##STR240##                                                               T.sup.229                                                                            ##STR241##                                                               T.sup.230                                                                            ##STR242##                                                               T.sup.231                                                                            ##STR243##                                                               T.sup.232                                                                            ##STR244##                                                               T.sup.233                                                                            ##STR245##                                                               T.sup.234                                                                            ##STR246##                                                               T.sup.235                                                                            ##STR247##                                                               T.sup.236                                                                            ##STR248##                                                               T.sup.237                                                                            ##STR249##                                                               T.sup.238                                                                            ##STR250##                                                               T.sup.239                                                                            ##STR251##                                                               T.sup.240                                                                            ##STR252##                                                               T.sup.241                                                                            ##STR253##                                                               T.sup.242                                                                            ##STR254##                                                               T.sup.243                                                                            ##STR255##                                                               T.sup.244                                                                            ##STR256##                                                               T.sup.245                                                                            ##STR257##                                                               T.sup.246                                                                            ##STR258##                                                               T.sup.247                                                                            ##STR259##                                                               T.sup.248                                                                            ##STR260##                                                               ______________________________________                                    

                                      TABLE I                                      __________________________________________________________________________      ##STR261##                                                                    Example                                                                        No.  R.sup.1                                                                            R.sup.2                                                                               R.sup.3                                                                            X  E    Q          M.p. [°C.]                       __________________________________________________________________________     1    H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.1    76-78                                   2    H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.2    oil                                     3    H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.3    oil                                     4    H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.4    oil                                     5    H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.5                                            6    H   (CH.sub.2).sub.4                                                                          O  --   T.sup.4                                            7    H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.4    oil                                     8    H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.4                                            9    H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.5, cis/trans = 1:2                                                                  oil                                     10   H   (CH.sub.2).sub.4                                                                          NH      T.sup.5, cis/trans = 2:1                                                                  oil                                     11   H   (CH.sub.2).sub.4                                                                          O  --   T.sup.6    104                                     12   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.6    76-77                                   13   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.6    oil                                     14   H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.6    94-98                                   15   H   C.sub.2 H.sub.5                                                                       Cl  O       T.sup.7    oil                                     16   H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.7    oil                                     17   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.7    oil                                     18   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.7    oil                                     19   H   (CH.sub.2).sub.4                                                                          O  --   T.sup.7    oil                                     20   CH.sub.3                                                                           C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.7                                            21   CH.sub.3                                                                           C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.7                                            22   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH CH.sub.2                                                                            T.sup.5    oil                                     23   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  CH.sub.2                                                                            T.sup.5    oil                                     24   H   (CH.sub.2).sub.4                                                                          O  CH.sub.2                                                                            T.sup.5    oil                                     25   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH H    T.sup.8    oil                                     26   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  H    T.sup.8    oil                                     27   H   C.sub.2 H.sub.5                                                                       Cl  NH H    T.sup.8    oil                                     28   H   C.sub.2 H.sub.5                                                                       Cl  O  H    T.sup.8    oil                                     29   H   (CH.sub.2).sub.4                                                                          O  H    T.sup.8    oil                                     30   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH H    T.sup.9    oil                                     31   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  H    T.sup.9    oil                                     32   H   C.sub.2 H.sub.5                                                                       Cl  NH H    T.sup.9    oil                                     33   H   C.sub.2 H.sub.5                                                                       Cl  O  H    T.sup.9                                            34   H   (CH.sub.2).sub.4                                                                          O  H    T.sup.9    oil                                     35   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH H    T.sup.10   oil                                     36   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  H    T.sup.10                                           37   H   C.sub.2 H.sub.5                                                                       Cl  NH H    T.sup.10   oil                                     38   H   C.sub.2 H.sub.5                                                                       Cl  O  H    T.sup.10                                           39   H   (CH.sub.2).sub.4                                                                          O  H    T.sup.10                                           40   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH H    T.sup.11   oil                                     41   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  H    T.sup.11                                           42   H   (CH.sub.2).sub.4                                                                          O  H    T.sup.11                                           43   H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.11   oil                                     44   H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.11                                           45   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.12                                           46   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.12                                           47   H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.12                                           48   H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.12                                           49   H   (CH.sub.2).sub.4                                                                          O  --   T.sup.12                                           50   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.13                                           51   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.13                                           52   H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.13                                           53   H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.13                                           54   H   (CH.sub.2).sub.4                                                                          O  --   T.sup.13   oil                                     55   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.14   oil                                     56   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.14                                           57   H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.14   80-81                                   58   H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.14                                           59   H   (CH.sub.2).sub.4                                                                          O  --   T.sup.14   69                                      60   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.15   78-80                                   61       CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.15                                           62       C.sub.2 H.sub.5                                                                       OCH.sub.3                                                                          NH --   T.sup.15                                           63       C.sub.2 H.sub.5                                                                       OCH.sub.3                                                                          O  --   T.sup.15                                           64       (CH.sub.2).sub.4                                                                          O  --   T.sup.15                                           65       CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.16                                           66   H   CH.sub.2 OCH.sub.3                                                                    Cl  O  --   T.sup.16                                           67   H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.16                                           68   H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.16                                           69   H   (CH.sub.2).sub.4                                                                          O  --   T.sup.16                                           70   H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.17                                           71   H   CH.sub.2 OCH.sub.3                                                                    Cl  O  --   T.sup.17                                           72   H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.17                                           73   H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.17                                           74   H   (CH.sub.2).sub.4                                                                          O  --   T.sup.17                                           75   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.18   69-70                                   76   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.18                                           77   H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.18                                           78   H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.18                                           79   H   (CH.sub.2).sub.4                                                                          O  --   T.sup.18                                           80   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.19   oil                                     81   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.19   oil                                     82   H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.19   oil                                     83   H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.19                                           84   H   (CH.sub.2).sub.4                                                                          O  --   T.sup.19   oil                                     85   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH CH.sub.2                                                                            T.sup.5    oil                                     86   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  CH.sub.2                                                                            T.sup.5    oil                                     87   H   (CH.sub.2).sub.4                                                                          O  CH.sub.2                                                                            T.sup.5    oil                                     88   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH CHCH.sub.3                                                                          T.sup.20   oil                                     89   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  CHCH.sub.3                                                                          T.sup.20                                           90   H   C.sub.2 H.sub.5                                                                       Cl  NH CHCH.sub.3                                                                          T.sup.20                                           91   H   C.sub.2 H.sub.5                                                                       Cl  O  CHCH.sub.3                                                                          T.sup.20                                           92   H   (CH.sub.2).sub.4                                                                          O  --   T.sup.20   oil                                     93   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.21, cis/trans = 2:1                                                                 oil                                     94   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.22   70-72                                   95   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.22   37                                      96   H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.22   79-80                                   97   H   (CH.sub.2).sub.4                                                                          NH --   T.sup.22   165-166                                 98   H   (CH.sub.2).sub.4                                                                          O  --   T.sup.22   112                                     99   H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.23   82-84                                   100  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.23   109                                     101  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.23   74-75                                   102  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.23                                           103  CH.sub.3                                                                           C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.23                                           104  CH.sub.3                                                                           C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.23                                           105  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.23   121-123                                 106  H   (CH.sub.2).sub.4)                                                                         O  --   T.sup.23   109                                     107  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    O  --   T.sup.23                                           108  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.24   oil                                     109  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.24                                           110  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.24   63-65                                   111  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.24                                           112  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.24   93-94                                   113  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.25                                           114  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.25                                           115  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.25                                           116  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.25                                           117  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.25                                           118  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.26                                           119  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.26                                           120  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.26                                           121  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.26                                           122  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.26                                           123  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.27                                           124  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.27                                           125  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.27                                           126  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.27                                           127  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.27                                           128  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.28                                           129  H   CH.sub.2 OCH.sub.3                                                                    Cl  O  --   T.sup.28                                           130  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.28                                           131  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.28                                           132  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.28                                           133  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.29                                           134  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.29                                           135  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.29                                           136  H   C.sub.2 H.sub.5                                                                       Cl  NH      T.sup.29                                           137  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.29                                           138  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.30   oil                                     139  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.30   oil                                     140  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.31                                           141  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.31                                           142  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.31                                           143  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.31                                           144  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.31                                           145  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.32                                           146  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.32                                           147  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.32                                           148  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.32                                           149  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.32                                           150  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH      T.sup.33                                           151  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O       T.sup.33                                           152  H   C.sub.2 H.sub.5                                                                       Cl  NH      T.sup.33                                           153  H   C.sub.2 H.sub.5                                                                       Cl  O       T.sup.33                                           154  H   (CH.sub.2).sub.4                                                                          O       T.sup.33                                           155  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.34   oil                                     156  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.35   oil                                     157  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.35                                           158  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.35                                           159  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.35                                           160  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.35                                           161  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.36                                           162  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.36                                           163  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.36                                           164  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.36                                           165  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.36                                           166  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.37                                           167  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.37                                           168  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.37                                           169  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.37                                           170  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.37                                           171  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.38                                           172  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.38                                           173  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.38                                           174  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.38                                           175  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.38                                           176  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.39                                           177  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.39                                           178  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.40                                           179  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.40                                           180  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.40                                           181  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.41                                           182  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.41                                           183  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.41                                           184  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.41                                           185  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.41                                           186  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.42                                           187  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.42                                           188  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.42                                           189  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.42                                           190  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.42                                           191  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.43                                           192  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.44   oil                                     193  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.44                                           194  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.44                                           195  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.44                                           196  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.44                                           197  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.45                                           198  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.46                                           199  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.45                                           200  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.45                                           201  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.45                                           202  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.46   60-62                                   203  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.47                                           204  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.47                                           205  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.48                                           206  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.48                                           207  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.49                                           208  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.50   solid                                   209  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.50                                           210  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.50                                           211  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.50                                           212  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.50                                           213  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.51                                           214  H   CH.sub.2 OCH.sub.3                                                                    Cl  O  --   T.sup.51                                           215  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.51                                           216  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.51                                           217  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.51                                           218      CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.52                                           219      CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.52                                           220  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.52                                           221  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.52                                           222  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.52                                           223  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.53   142-143                                 224  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.53   oil                                     225  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.53                                           226  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.54   83-85                                   227  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.54   oil                                     228  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.54    95-100                                 229  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.55   112-114                                 230  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.56                                           231  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH      T.sup.57                                           232  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.57                                           233  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.57                                           234  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.57                                           235  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.57                                           236  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.58   137-139                                 237  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.58                                           238  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.58                                           239  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.58                                           240  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.58                                           241  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.59   84-85                                   242  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.59                                           243  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.59   83-84                                   244  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.59                                           245  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.59   oil                                     246  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.60                                           247  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.60                                           248  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.60                                           249  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.60                                           250  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.60                                           251  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.61                                           252  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.61                                           253  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.61                                           254  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.61                                           255  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.61                                           256  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.62   95-96                                   257  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.62                                           258  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.62   101-102                                 259  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.62                                           260  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.62                                           261  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.63                                           262  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.63                                           263  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.63   81-83                                   264  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.63                                           265  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.63                                           266  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.64                                           267  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.64                                           268  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.64                                           269  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.64                                           270  H   (CH.sub.2).sub.4                                                                          -- --   T.sup.64                                           271  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.65                                           272  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.65                                           273  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.65                                           274  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.65                                           275  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.65                                           276  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.4                                            277  H   C.sub.2 C.sub.5                                                                       Br  NH --   T.sup.4                                            278  H   C.sub.2 C.sub.5                                                                       C.sub.2 C.sub.5                                                                    NH --   T.sup.4                                            279  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.7    oil                                     280  H   CH.sub.2 OCH.sub.3                                                                    C.sub.2 C.sub.5                                                                    NH --   T.sup.7    oil                                     281  H   CH.sub.2 OCH.sub.3                                                                    H   NH --   T.sup.7    oil                                     282  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.7                                            283  H   C.sub.2 H.sub.5                                                                       Br  NH --   T.sup.7                                            284  H   C.sub.2 H.sub.5                                                                       F   NH --   T.sup.7                                            285  H   CH.sub.3                                                                              Cl  NH --   T.sup.7                                            286  H   CH.sub.3                                                                              OCH.sub.3                                                                          NH --   T.sup.7                                            287  H   C.sub.2 H.sub.5                                                                       OCH.sub.3                                                                          NH --   T.sup.7                                            288  H   CH(CH.sub.3).sub.2                                                                    Cl  NH --   T.sup.7                                            289  H   cyclopropyl                                                                           Cl  NH --   T.sup.7                                            290  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.8                                            291  H   C.sub.2 H.sub.5                                                                       Br  NH --   T.sup.8                                            292  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.8                                            293  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.9                                            294  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.9                                            295  H   C.sub.2 H.sub.5                                                                       Br  NH --   T.sup.9                                            296  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.10                                           297  H   C.sub.2 H.sub.5                                                                       Br  NH --   T.sup.10                                           298  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.10                                           299  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.11                                           300  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    O  --   T.sup.11                                           301  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.11                                           302  H   C.sub.2 H.sub.5                                                                       Br  NH --   T.sup.11                                           303  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.14                                           304  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    O  --   T.sup.14                                           305  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.14                                           306  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.23   oil                                     307  H   CH.sub.2 OCH.sub.3                                                                    C.sub.2 H.sub.5                                                                    NH --   T.sup.23   78-79                                   308  H   CH.sub.2 OCH.sub.3                                                                    H   NH --   T.sup.23   oil                                     309  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.23                                           310  H   C.sub.2 H.sub.5                                                                       I   NH --   T.sup.23                                           311  H   C.sub.2 H.sub.5                                                                       F   NH --   T.sup.23                                           312  H   C.sub.2 H.sub.5                                                                       F   O  --   T.sup.23                                           313  H   C.sub.2 H.sub.5                                                                       Br  NH --   T.sup.23                                           314  H   CH.sub.3                                                                              Cl  NH --   T.sup.23                                           315  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.24   164-166                                 316  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.66                                           317  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.66   oil                                     318  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.66                                           319  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.66   oil                                     320  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.66                                           321  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.66   oil                                     322  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.66                                           323  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.66                                           324  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.67                                           325  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.67                                           326  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.67                                           327  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.67                                           328  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.67                                           329  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.68   oil                                     330  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.68   oil                                     331  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.68   oil                                     332  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.68   oil                                     333  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.68                                           334  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    O  --   T.sup.68                                           335  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.68                                           336  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.68   oil                                     337  H   C.sub.2 H.sub.5                                                                       Br  NH --   T.sup.68                                           338  H   C.sub.2 H.sub.5                                                                       Br  O  --   T.sup.68                                           339  H   C.sub.2 H.sub.5                                                                       F   NH --   T.sup.68                                           340  H   C.sub.2 H.sub.5                                                                       F   O  --   T.sup.68                                           341  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.68                                           342  H   CH.sub.2 OCH.sub.3                                                                    Cl  O  --   T.sup.68                                           343  H   CH.sub.3                                                                              Cl  NH --   T.sup.68                                           344  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.69                                           345  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.69                                           346  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.69                                           347  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.69                                           348  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.69                                           349  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.69   79-82                                   350  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.69                                           351  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    O  --   T.sup.69                                           352  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.70                                           352  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.70   oil                                     354  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.70                                           355  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.70   oil                                     356  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.70   oil                                     357  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.71   oil                                     358  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.71                                           359  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.71   oil                                     360  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.71                                           361  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.71                                           362  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.71                                           363  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.71                                           364  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    O  --   T.sup.71                                           365  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.72   oil                                     366  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.72                                           367  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.72                                           368  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.72                                           369  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.72                                           370  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.27                                           371  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.72                                           372  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    O  --   T.sup.72                                           373  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.73                                           374  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.73                                           375  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.73                                           376  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.73                                           377  H   (CH.sub.2).sub.4                                                                          O       T.sup.73                                           378  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.74                                           379  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.74   oil                                     380  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.74                                           381  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.74   87                                      382  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.74   86                                      383  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.75                                           384  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.76   oil                                     385  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.76   oil                                     386  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.76   oil                                     387  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.76   58                                      388  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.76                                           389  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.76    99-100                                 390  H   CH.sub.2 OCH.sub.3                                                                    C.sub.2 H.sub.5                                                                    NH --   T.sup.76   oil                                     391  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    NH --   T.sup.76                                           392  H   C.sub.2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                    O  --   T.sup.76                                           393  H   CH.sub.2 OCH.sub.3                                                                    Cl  NH --   T.sup.76                                           394  H   C.sub.2 H.sub.5                                                                       F   NH --   T.sup.76                                           395  H   C.sub.2 H.sub.5                                                                       Br  NH --   T.sup.76                                           396  H   CH.sub.3                                                                              Cl  NH --   T.sup.76                                           397  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.77   73-75                                   398  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.77   83                                      399  H   CH.sub.2 OCH.sub.3                                                                    C.sub.2 H.sub.5                                                                    NH --   T.sup.77   90-92                                   400  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.78                                           401  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.78                                           402  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.78   oil                                     403  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.78   oil                                     404  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.78   oil                                     405  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.79                                           406  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.79   78-79                                   407  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.80                                           408  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.80   oil                                     409  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.80   oil                                     410  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.80   oil                                     411  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.80   oil                                     412  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.81   72-74                                   413  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.81   oil                                     414  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.82                                           415  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.82   oil                                     416  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.82                                           417  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.82   65                                      418  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.82   68                                      419  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.84                                           420  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.84                                           421  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.84                                           422  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.84                                           423  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.84                                           424  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH      T.sup.85                                           425  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O       T.sup.85                                           426  H   C.sub.2 H.sub.5                                                                       Cl  NH      T.sup.85                                           427  H   C.sub.2 H.sub.5                                                                       Cl  O       T.sup.85                                           428  H   (CH.sub.2).sub.4                                                                          O       T.sup.85                                           429  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.86                                           430  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.86                                           431  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.86                                           432  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.86                                           433  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.86                                           434  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.87                                           435  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.87   oil                                     436  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.87   oil                                     437  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.87   57                                      438  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.87   67                                      439  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.88   65-66                                   440  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.89   oil                                     441  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.89   oil                                     442  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.89   oil                                     443  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.89   53                                      444  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.89   59                                      445  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.90   oil                                     446  H   C.sub.2 H.sub.5                                                                       OCH.sub.3                                                                          NH --   T.sup.90   63-65                                   447  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.91                                           448  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.91                                           449  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.91                                           450  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.91                                           451  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.91                                           452  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.92                                           453  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.92                                           454  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.92                                           455  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.92                                           456  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.92                                           457  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.93                                           458  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.93                                           459  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.93                                           460  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.93                                           461  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.93                                           462  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.93                                           463  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.94                                           464  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.94                                           465  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.94   oil                                     466  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.94   58-60                                   467  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.94   oil                                     468  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.95                                           469  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.95                                           470  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.95   oil                                     471  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.95   oil                                     472  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.95   oil                                     473  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.96   oil                                     474  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.97                                           475  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.97                                           476  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.97                                           477  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.97   71                                      478  H   (CH.sub.2).sub.4                                                                          NH --   T.sup.97                                           479  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.97   oil                                     480  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.98                                           481  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.98                                           482  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.98                                           483  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.98                                           484  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.98   oil                                     485  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.99                                           486  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.99                                           487  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.99                                           488  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.99                                           489  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.99                                           490  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.100                                          491  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.100                                          492  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.100                                          493  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.100                                          494  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.100                                          495  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.101                                          496  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.101                                          497  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.101                                          498  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.101                                          499  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.101                                          500  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.102                                          501  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.102                                          502  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.102                                          503  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.102                                          504  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.102                                          505  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.103                                          506  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.103                                          507  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.103                                          508  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.103                                          509  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.103                                          510  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.104                                          511  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.104  oil                                     512  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.104                                          513  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.104  100-103                                 514  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.104  108-112                                 515  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.105                                          516  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.105                                          517  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.105                                          518  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.105                                          519  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.105                                          520  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.106                                          521  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.106                                          522  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.106                                          523  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.106                                          524  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.106                                          525  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.107                                          526  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.107  oil                                     527  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.107                                          528  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.107  oil                                     529  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.107  oil                                     530  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.108                                          531  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.108                                          532  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.108                                          533  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.108                                          534  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.108                                          535  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.109                                          536  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.109                                          537  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.109                                          538  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.109                                          539  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.109                                          540  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.110                                          541  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.110                                          542  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.110                                          543  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.110                                          544  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.110                                          545  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.111                                          546  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.111                                          547  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.111                                          548  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.111                                          549  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.111                                          550  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.112                                          551  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.112                                          552  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.112                                          553  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.112                                          554  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.112  oil                                     555  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.113                                          556  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.113                                          557  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.113                                          558  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.113                                          559  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.113                                          560  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.114                                          561  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.114                                          562  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.114                                          563  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.114  oil                                     564  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.114                                          565  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.115                                          566  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.115  oil                                     567  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.115  oil                                     568  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.115                                          569  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.115  oil                                     570  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.116  oil                                     571  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.117                                          572  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.117                                          573  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.117                                          574  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.117                                          575  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.117                                          576  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.118                                          577  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.118  oil                                     578  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.118                                          579  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.118  oil                                     580  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.118  oil                                     581  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.119                                          582  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.119                                          583  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.119                                          584  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.119                                          585  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.119                                          586  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.120                                          587  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.120                                          588  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.120                                          589  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.120                                          590  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.120                                          591  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.121                                          592  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.121                                          593  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.121                                          594  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.121                                          595  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.121                                          596  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.122                                          597  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.122                                          598  H   C.sub.2 H.sub.5                                                                       CL  NH --   T.sup.122                                          599  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.122                                          600  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.122                                          601  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.123                                          602  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.123  oil                                     603  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.123                                          604  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.123                                          605  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.123  63-73                                   606  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.124                                          607  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.124                                          608  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.124                                          609  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.124                                          610  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.124                                          611  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.125                                          612  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.125                                          613  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.125                                          614  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.125                                          615  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.125                                          616  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.126                                          617  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.126                                          618  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.126                                          619  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.126                                          620  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.126                                          621  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.127                                          622  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.127                                          623  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.127                                          624  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.127                                          625  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.127                                          626  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.128                                          627  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.128                                          628  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.128                                          629  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.128                                          630  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.128                                          631  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.129                                          632  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.129                                          633  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.129                                          634  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.129                                          635  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.129                                          636  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.130                                          637  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.130                                          638  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.130                                          639  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.130                                          640  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.130                                          641  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.131                                          642  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.131                                          643  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.131                                          644  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.131                                          645  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.131                                          646  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.132                                          647  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.132                                          648  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.132                                          649  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.132                                          650  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.132                                          651  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.133                                          652  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.133                                          653  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.133                                          654  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.133                                          655  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.133                                          656  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.134                                          657  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.134                                          658  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.134                                          659  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.134                                          660  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.134                                          661  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.135                                          662  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.135                                          663  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.135                                          664  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.135                                          665  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.135                                          666  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.136                                          667  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.136                                          668  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.136                                          669  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.136                                          670  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.136                                          671  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.137                                          672  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.137                                          673  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.137                                          674  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.137                                          675  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.137                                          676  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.138                                          677  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.138                                          678  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.138                                          679  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.138                                          680  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.138                                          681  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.139                                          682  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.139                                          683  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.139                                          684  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.139                                          685  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.139                                          686  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.140                                          687  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.140                                          688  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.140                                          689  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.140                                          690  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.140                                          691  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.141                                          692  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.141                                          693  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.141  65-66                                   694  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.141                                          695  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.141                                          696  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.142                                          697  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.142                                          698  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.142                                          699  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.142                                          700  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.142                                          701  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.143                                          702  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.143                                          703  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.143                                          704  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.143                                          705  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.143                                          706  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.144                                          707  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.144                                          708  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.144                                          709  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.144                                          710  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.144                                          711  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.145                                          712  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.145                                          713  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.145                                          714  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.145                                          715  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.145                                          716  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.146                                          717  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.146                                          718  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.146                                          719  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.146                                          720  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.146                                          721  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.147                                          722  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.147                                          723  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.147                                          724  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.147                                          725  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.147                                          726  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.148                                          727  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.148                                          728  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.148                                          729  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.148                                          730  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.148                                          731  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.149                                          732  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.149                                          733  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.149                                          734  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.149                                          735  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.149                                          736  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.150                                          737  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.150                                          738  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.150                                          739  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.150                                          740  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.150                                          741  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.151  93-94                                   742  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.151  oil                                     743  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.151  110-111                                 744  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.151  72                                      745  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.151  108                                     746  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.152  oil                                     747  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.152                                          748  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.152  87-88                                   749  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.152                                          750  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.152                                          751  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.153                                          752  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.153                                          753  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.153                                          754  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.153                                          755  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.153                                          756  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.154                                          757  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.154                                          758  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.154  oil                                     759  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.154                                          760  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.154                                          761  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.155                                          762  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.155                                          763  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.155  oil                                     764  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.155                                          765  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.155                                          766  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.156                                          767  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.156                                          768  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.156                                          769  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.156                                          770  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.156                                          771  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.157                                          772  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.157                                          773  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.157                                          774  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.157                                          775  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.157                                          776  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.158                                          777  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.158                                          778  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.158                                          779  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.158                                          780  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.158                                          781  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.159                                          782  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.159                                          783  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.159                                          784  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.159                                          785  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.159                                          786  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.160  oil                                     787  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.160                                          788  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.160  oil                                     789  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.160                                          790  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.160                                          791  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.161  oil                                     792  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.161                                          793  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.161  oil                                     794  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.161                                          795  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.161                                          796  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.162                                          797  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.162                                          798  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.162                                          799  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.162                                          800  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.162                                          801  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.163                                          802  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.163                                          803  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.163                                          804  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.163                                          805  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.163                                          806  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.164                                          807  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.164                                          808  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.164                                          809  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.164                                          810  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.164                                          811  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.165                                          812  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.165                                          813  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.165                                          814  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.165                                          815  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.165                                          816  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.166                                          817  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.166                                          818  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.166                                          819  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.166                                          820  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.166                                          821  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.167                                          822  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.167                                          823  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.167                                          824  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.167                                          825  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.167                                          826  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.168                                          827  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.168                                          828  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.168                                          829  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.168                                          830  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.168                                          831  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.169                                          832  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.169                                          833  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.169                                          834  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.169                                          835  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.169                                          836  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.170                                          837  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.170                                          838  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.170                                          839  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.170                                          840  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.170                                          841  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.171                                          842  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.171                                          843  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.171                                          844  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.171                                          845  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.171                                          846  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.172                                          847  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.172                                          848  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.172                                          849  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.172                                          850  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.172                                          851  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.173                                          852  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.173                                          853  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.173                                          854  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.173                                          855  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.173                                          856  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.174                                          857  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.174                                          858  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.174  oil                                     859  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.174                                          860  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.174                                          861  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.175                                          862  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.175                                          863  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.175  oil                                     864  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.175                                          865  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.175                                          866  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.176                                          867  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.176                                          868  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.176                                          869  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.176                                          870  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.176                                          871  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.177                                          872  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.177                                          873  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.177                                          874  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.177                                          875  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.177                                          876  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.178                                          877  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.178                                          878  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.178                                          879  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.178                                          880  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.178                                          881  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.179                                          882  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.179                                          883  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.179                                          884  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.179                                          885  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.179                                          886  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.180                                          887  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.180                                          888  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.180  oil                                     889  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.180                                          890  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.180                                          891  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.181                                          892  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.181                                          893  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.181                                          894  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.181                                          895  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.181                                          896  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.182                                          897  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.182                                          898  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.182                                          899  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.182                                          900  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.182                                          901  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.183                                          902  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.183                                          903  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.183                                          904  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.183                                          905  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.183                                          906  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.184                                          907  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.184                                          908  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.184                                          909  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.184                                          910  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.184                                          911  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.185                                          912  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.185                                          913  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.185                                          914  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.185                                          915  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.185                                          916  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.186                                          917  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.186                                          918  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.186  oil                                     919  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.186                                          920  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.186                                          921  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.187                                          922  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.187                                          923  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.187                                          924  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.187                                          925  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.187                                          926  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.188                                          927  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.188                                          928  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.188                                          929  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.188                                          930  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.188                                          931  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.189                                          932  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.189                                          933  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.189                                          934  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.189                                          935  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.189                                          936  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.190                                          937  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.190                                          938  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.190                                          939  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.190                                          940  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.190                                          941  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.191                                          942  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.191                                          943  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.191                                          944  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.191                                          945  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.191                                          946  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.192                                          947  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.192                                          948  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.192                                          949  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.192                                          950  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.192                                          951  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.193                                          952  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.193                                          953  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.193                                          954  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.193                                          955  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.193                                          956  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.194                                          957  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.194                                          958  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.194                                          959  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.194                                          960  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.194                                          961  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.195                                          962  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.195                                          963  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.195                                          964  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.195                                          965  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.195                                          966  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.196                                          967  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.196                                          968  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.196                                          969  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.196                                          970  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.196                                          971  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.197                                          972  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.197                                          973  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.197                                          974  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.197                                          975  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.197                                          976  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.198                                          977  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.198                                          978  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.198                                          979  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.198                                          980  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.198                                          981  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.199                                          982  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.199                                          983  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.199                                          984  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.199                                          985  H   (CH.sub.2).sub.4                                                                          O  --   T.sup.199                                          986  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.200                                          987  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.200                                          988  H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.200                                          989  H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.200                                          990  H   (CH.sub.2).sub.4                                                                          -- O    T.sup.200                                          991  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          -- NH   T.sup.201                                          992  H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          -- O    T.sup.201                                          993  H   C.sub.2 H.sub.5                                                                       Cl  -- NH   T.sup.201                                          994  H   C.sub.2 H.sub.5                                                                       Cl  -- O    T.sup.201                                          995  H   (CH.sub.2).sub.4                                                                          -- O    T.sup.201                                          996  H   C.sub.2 H.sub.5                                                                       Cl  -- NH   T.sup.4    177-178                                 997  H   C.sub.2 H.sub.5                                                                       Cl  -- NH   T.sup.7    177-178                                 998  H   C.sub.2 H.sub.5                                                                       I   -- NH   T.sup.7                                            999  H   C.sub.2 H.sub.5                                                                       I   -- NH   T.sup.14                                           1000 H   (CH.sub.2).sub.2 CH.sub.3                                                             Cl  -- NH   T.sup.23                                           1001 H   C.sub.2 H.sub.5                                                                       I   -- NH   T.sup.76                                           1002 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          -- NH   T.sup.202                                          1003 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          -- O    T.sup.202                                          1004 H   C.sub.2 H.sub.5                                                                       Cl  -- NH   T.sup.202                                          1005 H   C.sub.2 H.sub.5                                                                       OCH.sub.3                                                                          -- O    T.sup.202                                          1006 H   (CH.sub.2).sub.4                                                                          -- O    T.sup.202                                          1007 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.203                                          1008 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.203                                          1009 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.203                                          1010 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.203                                          1011 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.203                                          1012 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.204                                          1013 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.204                                          1014 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.204                                          1015 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.204                                          1016 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.204                                          1017 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.205                                          1018 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.205                                          1019 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.205                                          1020 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.205                                          1021 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.205                                          1022 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.206                                          1023 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.206                                          1024 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.206                                          1025 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.206                                          1026 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.206                                          1027 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.207                                          1028 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.207                                          1029 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.207                                          1030 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.207                                          1031 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.207                                          1032 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.208                                          1033 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.208                                          1034 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.208                                          1035 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.208                                          1036 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.208                                          1037 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.209                                          1038 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.209                                          1039 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.209                                          1040 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.209                                          1041 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.209                                          1042 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.210                                          1043 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.210                                          1044 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.210                                          1045 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.210                                          1046 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.210                                          1047 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.211                                          1048 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.211                                          1049 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.211                                          1050 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.211                                          1051 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.211                                          1052 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.212                                          1053 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.212                                          1054 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.212                                          1055 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.212                                          1056 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.212                                          1057 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.213                                          1058 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          -- O    T.sup.213                                          1059 H   C.sub.2 H.sub.5                                                                       Cl  -- NH   T.sup.213                                          1060 H   C.sub.2 H.sub.5                                                                       Cl  -- O    T.sup.213                                          1061 H   (CH.sub.2).sub.4                                                                          -- O    T.sup.213                                          1062 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          -- NH   T.sup.214                                          1063 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          -- O    T.sup.214                                          1064 H   C.sub.2 H.sub.5                                                                       Cl  -- NH   T.sup.214                                          1065 H   C.sub.2 H.sub.5                                                                       Cl  -- O    T.sup.214                                          1066 H   (CH.sub.2).sub.4                                                                          -- O    T.sup.214                                          1067 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          -- NH   T.sup.215                                          1068 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          -- O    T.sup.215                                          1069 H   C.sub.2 H.sub.5                                                                       Cl  -- NH   T.sup.215                                          1070 H   C.sub.2 H.sub.5                                                                       Cl  -- O    T.sup.215                                          1071 H   (CH.sub.2).sub.4                                                                          -- O    T.sup.215                                          1072 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          -- NH   T.sup.216                                          1073 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          -- O    T.sup.216                                          1074 H   C.sub.2 H.sub.5                                                                       Cl  -- NH   T.sup.216                                          1075 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.216                                          1076 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.216                                          1072 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.217                                          1078 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.217                                          1079 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.217                                          1080 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.217                                          1081 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.217                                          1082 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.218                                          1083 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.218                                          1084 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.218                                          1085 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.218                                          1086 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.218                                          1087 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.219                                          1088 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.219                                          1089 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.219                                          1090 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.219                                          1091 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.219                                          1092 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.220                                          1093 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.220                                          1094 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.220                                          1095 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.220                                          1096 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.220                                          1097 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.221                                          1098 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.221                                          1099 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.221                                          1100 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.221                                          1101 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.221                                          1102 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.222                                          1103 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.222                                          1104 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.222                                          1105 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.222                                          1106 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.222                                          1107 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.223                                          1108 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.223                                          1109 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.223                                          1110 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.223                                          1111 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.223                                          1112 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.225                                          1113 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.225                                          1114 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.225                                          1115 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.225                                          1116 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.225                                          1117 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.226                                          1118 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.226                                          1119 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.226                                          1120 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.226                                          1121 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.226                                          1122 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.227                                          1123 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.227                                          1124 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.227                                          1125 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.227                                          1126 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.227                                          1127 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.228                                          1128 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.228                                          1129 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.228                                          1130 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.228                                          1131 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.228                                          1132 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.229                                          1133 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.229                                          1134 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.229                                          1135 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.229                                          1136 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.229                                          1137 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.230                                          1138 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.230                                          1139 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.230                                          1140 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.230                                          1141 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.230                                          1142 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.231                                          1143 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.231                                          1144 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.231                                          1145 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.231                                          1146 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.231                                          1147 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.232                                          1148 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.232                                          1149 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.232                                          1150 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.232                                          1151 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.232                                          1152 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.233                                          1153 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.233                                          1154 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.233                                          1155 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.233                                          1156 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.233                                          1157 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.234                                          1158 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.234                                          1159 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.234                                          1160 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.234                                          1161 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.234                                          1162 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.235                                          1163 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.235                                          1164 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.235                                          1165 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.235                                          1166 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.235                                          1167 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.236                                          1168 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.236                                          1169 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.236                                          1170 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.236                                          1171 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.236                                          1172 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.237                                          1173 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.237                                          1174 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.237                                          1175 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.237                                          1176 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.237                                          1177 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.238                                          1178 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.238                                          1179 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.238                                          1180 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.238                                          1181 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.238                                          1182 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.239                                          1183 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.239                                          1184 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.239                                          1185 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.239                                          1186 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.239                                          1187 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.240                                          1188 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.240                                          1189 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.240                                          1190 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.240                                          1191 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.240                                          1192 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.241                                          1193 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.241                                          1194 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.241                                          1195 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.241                                          1196 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.241                                          1197 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.242                                          1198 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.242                                          1199 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.242                                          1200 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.242                                          1201 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.242                                          1202 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.243                                          1203 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.243                                          1204 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.243                                          1205 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.243                                          1206 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.243                                          1207 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.244                                          1208 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.244                                          1209 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.244                                          1210 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.244                                          1211 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.244                                          1212 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.245                                          1213 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.245                                          1214 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.245                                          1215 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.245                                          1216 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.245                                          1217 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.246                                          1218 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.246                                          1219 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.246                                          1220 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.246                                          1221 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.246                                          1222 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.247                                          1223 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.247                                          1224 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.247                                          1225 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.247                                          1226 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.247                                          1227 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          NH --   T.sup.248                                          1228 H   CH.sub.2 OCH.sub.3                                                                    OCH.sub.3                                                                          O  --   T.sup.248                                          1229 H   C.sub.2 H.sub.5                                                                       Cl  NH --   T.sup.248                                          1230 H   C.sub.2 H.sub.5                                                                       Cl  O  --   T.sup.248                                          1231 H   (CH.sub.2).sub.4                                                                          O  --   T.sup.248                                          __________________________________________________________________________

                  TABLE II                                                         ______________________________________                                          ##STR262##                                                                    Example                                       M.p.                             No.    R.sup.7                                                                               R.sup.8                                                                               R.sup.9                                                                             R.sup.10                                                                            X    E    Q    [°C.]                     ______________________________________                                         1232   H      H      H    H    NH   --   T.sup.7                                                                             135-137                          1233   H      H      H    H    O    --   T.sup.7                               1234   H      Cl     H    H    NH   --   T.sup.7                               1235   H      Cl     H    H    O    --   T.sup.7                               1236   H      H      Cl   H    NH   --   T.sup.7                               1237   H      H      Cl   H    O    --   T.sup.7                               1238   CH.sub.3                                                                              H      H    H    NH   --   T.sup.7                               1239   CH.sub.3                                                                              H      H    H    O    --   T.sup.7                               1240   H      H      CH.sub.3                                                                            H    NH   --   T.sup.7                               1241   H      H      CH.sub.3                                                                            H    O    --   T.sup.7                               1242   H      H      H    CH.sub.3                                                                            NH   --   T.sup.7                               1243   H      H      H    CH.sub.3                                                                            O    --   T.sup.7                               1244   H      H      H    H    NH   --   T.sup.6                                                                             140-142                          1245   H      H      H    H    NH   --   T.sup.9                                                                             90-92                            1246   H      H      H    H    O    --   T.sup.9                                                                             oil                              1247   H      H      H    H    NH   --   T.sup.8                                                                             143-145                          1248   H      H      H    H    O    --   T.sup.8                               1249   H      H      H    H    NH   --   T.sup.4                                                                             158-160                          1250   H      H      H    H    O    --   T.sup.4                               1251   H      H      H    H    NH   --   T.sup.10                              1252   H      H      H    H    O    --   T.sup.10                              1253   H      H      H    H    NH   --   T.sup.11                              1254   H      H      H    H    O    --   T.sup.11                              1255   H      H      H    H    NH   --   T.sup.12                              1256   H      H      H    H    O    --   T.sup.12                              1257   H      H      H    H    NH   --   T.sup.14                              1258   H      H      H    H    O    --   T.sup.14                              1259   H      H      H    H    NH   --   T.sup.22                                                                            210-211                          1260   H      H      H    H    NH   --   T.sup.23                                                                            153-155                          1261   H      H      H    H    O    --   T.sup.23                              1262   H      H      H    H    NH   --   T.sup.23                              1263   F      H      H    H    O    --   T.sup.23                              1264   H      H      Cl   H    NH   --   T.sup.23                              1265   H      H      Cl   H    O    --   T.sup.23                              1266   Cl     H      H    H    NH   --   T.sup.23                              1267   Cl     H      H    H    O    --   T.sup.23                              1268   H      H      CH.sub.3                                                                            H    NH   --   T.sup.23                              1269   H      H      CH.sub.3                                                                            H    O    --   T.sup.23                              1270   H      H      H    CH.sub.3                                                                            NH   --   T.sup.23                              1271   H      H      H    CH.sub.3                                                                            O    --   T.sup.23                              1272   H      H      H    H    NH   --   T.sup.58                                                                            184-185                          1273   H      H      H    H    NH   --   T.sup.13                              1274   H      H      H    H    O    --   T.sup.13                              1275   H      H      H    H    NH   --   T.sup.16                              1276   H      H      H    H    O    --   T.sup.16                              1277   H      H      H    H    NH   --   T.sup.17                              1278   H      H      H    H    O    --   T.sup.17                              1279   H      H      H    H    NH   --   T.sup.19                              1280   H      H      H    H    O    --   T.sup.19                              1281   H      H      H    H    NH   --   T.sup.24                                                                            155-157                          1282   H      H      H    H    O    --   T.sup.24                              1283   H      H      H    H    NH   --   T.sup.25                              1284   H      H      H    H    O    --   T.sup.25                              1285   H      H      H    H    NH   --   T.sup.26                              1286   H      H      H    H    O    --   T.sup.26                              1287   H      H      H    H    NH   --   T.sup.27                              1288   H      H      H    H    O    --   T.sup.27                              1289   H      H      H    H    NH   --   T.sup.28                              1290   H      H      H    H    O    --   T.sup.28                              1291   H      H      H    H    NH   --   T.sup.29                              1292   H      H      H    H    O    --   T.sup.29                              1293   H      H      H    H    NH   --   T.sup.30                              1294   H      H      H    H    O    --   T.sup.30                              1295   H      H      H    H    NH   --   T.sup.31                              1296   H      H      H    H    O    --   T.sup.31                              1297   H      H      H    H    NH   --   T.sup.32                              1298   H      H      H    H    O    --   T.sup.32                              1299   H      H      H    H    NH   --   T.sup.33                              1300   H      H      H    H    O    --   T.sup.33                              1301   H      H      H    H    NH   --   T.sup.34                              1302   H      H      H    H    O    --   T.sup.34                              1303   H      H      H    H    NH   --   T.sup.35                              1304   H      H      H    H    O    --   T.sup.35                              1305   H      H      H    H    NH   --   T.sup.36                              1306   H      H      H    H    O    --   T.sup.36                              1307   H      H      H    H    NH   --   T.sup.37                              1308   H      H      H    H    O    --   T.sup.37                              1309   H      H      H    H    NH   --   T.sup.38                              1310   H      H      H    H    O    --   T.sup.38                              1311   H      H      H    H    NH   --   T.sup.39                              1312   H      H      H    H    O    --   T.sup.39                              1313   H      H      H    H    NH   --   T.sup.40                              1314   H      H      H    H    O    --   T.sup.40                              1315   H      H      H    H    NH   --   T.sup.41                              1316   H      H      H    H    O    --   T.sup.41                              1317   H      H      H    H    NH   --   T.sup.42                              1318   H      H      H    H    O    --   T.sup.42                              1319   H      H      H    H    NH   --   T.sup.44                              1320   H      H      H    H    O    --   T.sup.44                              1321   H      H      H    H    NH   --   T.sup.45                              1322   H      H      H    H    O    --   T.sup.45                              1323   H      H      H    H    NH   --   T.sup.47                              1324   H      H      H    H    O    --   T.sup.47                              1325   H      H      H    H    NH   --   T.sup.50                              1326   H      H      H    H    O    --   T.sup.50                              1327   H      H      H    H    NH   --   T.sup.51                              1328   H      H      H    H    O    --   T.sup.51                              1329   H      H      H    H    NH   --   T.sup.52                              1330   H      H      H    H    O    --   T.sup.52                              1331   H      H      H    H    NH   --   T.sup.54                              1332   H      H      H    H    O    --   T.sup.54                              1333   H      H      H    H    NH   --   T.sup.55                              1334   H      H      H    H    O    --   T.sup.55                                                                            121                              1335   H      H      H    H    NH   --   T.sup.56                              1336   H      H      H    H    O    --   T.sup.56                              1337   H      H      H    H    NH   --   T.sup.59                                                                            144-145                          1338   H      H      H    H    O    --   T.sup.59                              1339   H      H      H    H    NH   --   T.sup.60                              1340   H      H      H    H    O    --   T.sup.60                              1341   H      H      H    H    NH   --   T.sup.61                              1342   H      H      H    H    O    --   T.sup.61                              1343   H      H      H    H    NH   --   T.sup.62                                                                            176                              1344   H      H      H    H    O    --   T.sup.62                                                                            117                              1345   H      H      H    H    NH   --   T.sup.66                              1346   H      H      H    H    O    --   T.sup.66                                                                            oil                              1347   H      H      H    H    NH   --   T.sup.67                              1348   H      H      H    H    O    --   T.sup.67                              1349   H      H      H    H    NH   --   T.sup.68                                                                            glass                            1350   H      H      H    H    O    --   T.sup.68                                                                            oil                              1351   H      H      H    H    NH   --   T.sup.69                              1352   H      H      H    H    O    --   T.sup.69                                                                            69-72                            1353   H      H      H    H    NH   --   T.sup.70                              1354   H      H      H    H    O    --   T.sup.70                              1355   H      H      H    H    NH   --   T.sup.72                              1356   H      H      H    H    O    --   T.sup.72                              1357   H      H      H    H    NH   --   T.sup.73                              1358   H      H      H    H    O    --   T.sup.73                              1359   H      H      H    H    NH   --   T.sup.74                              1360   H      H      H    H    O    --   T.sup.74                                                                            161                              1361   H      H      H    H    NH   --   T.sup.75                              1362   H      H      H    H    O    --   T.sup.75                              1363   H      H      H    H    NH   --   T.sup.76                                                                            160-161                          1364   H      H      H    H    O    --   T.sup.76                                                                            103                              1365   H      H      H    H    NH   --   T.sup.77                                                                            224-225                          1366   H      H      H    H    O    --   T.sup.77                              1367   H      H      H    H    NH   --   T.sup.78                              1368   H      H      H    H    O    --   T.sup.78                              1369   H      H      H    H    NH   --   T.sup.79                              1370   H      H      H    H    O    --   T.sup.79                              1371   H      H      H    H    NH   --   T.sup.80                              1372   H      H      H    H    O    --   T.sup.80                                                                            104                              1373   H      H      H    H    NH   --   T.sup.81                              1374   H      H      H    H    O    --   T.sup.81                              1375   H      H      H    H    NH   --   T.sup.82                                                                            134-136                          1376   H      H      H    H    O    --   T.sup.82                              1377   H      H      H    H    NH   --   T.sup.83                                                                            158-160                          1378   H      H      H    H    O    --   T.sup.83                              1379   H      H      H    H    NH   --   T.sup.84                              1380   H      H      H    H    O    --   T.sup.84                              1381   H      H      H    H    NH   --   T.sup.85                              1382   H      H      H    H    O    --   T.sup.85                              1383   H      H      H    H    NH   --   T.sup.86                              1384   H      H      H    H    O    --   T.sup.86                              1385   H      H      H    H    NH   --   T.sup.87                                                                            123-124                          1386   H      H      H    H    O    --   T.sup.87                                                                             75                              1387   H      H      H    H    NH   --   T.sup.88                                                                            156-157                          1388   H      H      H    H    O    --   T.sup.88                              1389   H      H      H    H    NH   --   T.sup.89                              1390   H      H      H    H    O    --   T.sup.89                                                                             65                              1391   H      H      H    H    NH   --   T.sup.90                              1392   H      H      H    H    O    --   T.sup.90                              1393   H      H      H    H    NH   --   T.sup.91                              1394   H      H      H    H    O    --   T.sup.91                              1395   H      H      H    H    NH   --   T.sup.92                              1396   H      H      H    H    O    --   T.sup.92                              1397   H      H      H    H    NH   --   T.sup.93                              1398   H      H      H    H    O    --   T.sup.93                              1399   H      H      H    H    NH   --   T.sup.94                              1400   H      H      H    H    O    --   T.sup.94                                                                            78-81                            1401   H      H      H    H    NH   --   T.sup.95                              1402   H      H      H    H    O    --   T.sup.95                                                                             57                              1403   H      H      H    H    NH   --   T.sup.96                              1404   H      H      H    H    O    --   T.sup.96                              1405   H      H      H    H    NH   --   T.sup.97                              1406   H      H      H    H    O    --   T.sup.97                                                                             97                              1407   H      H      H    H    NH   --   T.sup.98                              1408   H      H      H    H    O    --   T.sup.98                              1409   H      H      H    H    NH   --   T.sup.99                              1410   H      H      H    H    O    --   T.sup.99                              1411   H      H      H    H    NH   --   T.sup.100                             1412   H      H      H    H    O    --   T.sup.100                             1413   H      H      H    H    NH   --   T.sup.101                             1414   H      H      H    H    O    --   T.sup.101                             1415   H      H      H    H    NH   --   T.sup.102                             1416   H      H      H    H    O    --   T.sup.102                             1417   H      H      H    H    NH   --   T.sup.103                             1418   H      H      H    H    O    --   T.sup.103                             1419   H      H      H    H    NH   --   T.sup.104                             1420   H      H      H    H    O    --   T.sup.104                                                                           107                              1421   H      H      H    H    NH   --   T.sup.105                             1422   H      H      H    H    O    --   T.sup.105                             1423   H      H      H    H    NH   --   T.sup.106                             1424   H      H      H    H    O    --   T.sup.106                             1425   H      H      H    H    NH   --   T.sup.107                             1426   H      H      H    H    O    --   T.sup.107                                                                           oil                              1427   H      H      H    H    NH   --   T.sup.108                             1428   H      H      H    H    O    --   T.sup.108                             1429   H      H      H    H    NH   --   T.sup.109                             1430   H      H      H    H    O    --   T.sup.109                             1431   H      H      H    H    NH   --   T.sup.110                             1432   H      H      H    H    O    --   T.sup.110                             1433   H      H      H    H    NH   --   T.sup.111                             1434   H      H      H    H    O    --   T.sup.111                                                                           oil                              1435   H      H      H    H    NH   --   T.sup.112                             1436   H      H      H    H    O    --   T.sup.112                                                                           oil                              1437   H      H      H    H    NH   --   T.sup.113                             1438   H      H      H    H    O    --   T.sup.113                             1439   H      H      H    H    NH   --   T.sup.114                             1440   H      H      H    H    O    --   T.sup.114                             1441   H      H      H    H    NH   --   T.sup.115                             1442   H      H      H    H    O    --   T.sup.115                                                                           oil                              1443   H      H      H    H    NH   --   T.sup.116                             1444   H      H      H    H    O    --   T.sup.116                             1445   H      H      H    H    NH   --   T.sup.117                             1446   H      H      H    H    O    --   T.sup.117                             1447   H      H      H    H    NH   --   T.sup.118                             1448   H      H      H    H    O    --   T.sup.118                                                                           oil                              1449   H      H      H    H    NH   --   T.sup.119                             1450   H      H      H    H    O    --   T.sup.119                             1451   H      H      H    H    NH   --   T.sup.120                             1452   H      H      H    H    O    --   T.sup.120                             1453   H      H      H    H    NH   --   T.sup.121                             1454   H      H      H    H    O    --   T.sup.121                             1455   H      H      H    H    NH   --   T.sup.122                             1456   H      H      H    H    O    --   T.sup.122                                                                           oil                              1457   H      H      H    H    NH   --   T.sup.123                             1458   H      H      H    H    O    --   T.sup.123                                                                            80                              1459   H      H      H    H    NH   --   T.sup.124                             1460   H      H      H    H    O    --   T.sup.124                             1461   H      H      H    H    NH   --   T.sup.125                             1462   H      H      H    H    O    --   T.sup.125                             1463   H      H      H    H    NH   --   T.sup.126                             1464   H      H      H    H    O    --   T.sup.126                             1465   H      H      H    H    NH   --   T.sup.127                             1466   H      H      H    H    O    --   T.sup.127                             1467   H      H      H    H    NH   --   T.sup.128                             1468   H      H      H    H    O    --   T.sup.128                             1469   H      H      H    H    NH   --   T.sup.129                             1470   H      H      H    H    O    --   T.sup.129                             1471   H      H      H    H    NH   --   T.sup.130                             1472   H      H      H    H    O    --   T.sup.130                             1473   H      H      H    H    NH   --   T.sup.131                             1474   H      H      H    H    O    --   T.sup.131                             1475   H      H      H    H    NH   --   T.sup.132                             1476   H      H      H    H    O    --   T.sup.132                             1477   H      H      H    H    NH   --   T.sup.133                             1478   H      H      H    H    O    --   T.sup.133                             1479   H      H      H    H    NH   --   T.sup.134                             1480   H      H      H    H    O    --   T.sup.134                             1481   H      H      H    H    NH   --   T.sup.135                             1482   H      H      H    H    O    --   T.sup.135                             1483   H      H      H    H    NH   --   T.sup.136                             1484   H      H      H    H    O    --   T.sup.136                             1485   H      H      H    H    NH   --   T.sup.137                             1486   H      H      H    H    O    --   T.sup.137                             1487   H      H      H    H    NH   --   T.sup.138                             1488   H      H      H    H    O    --   T.sup.138                             1489   H      H      H    H    NH   --   T.sup.139                             1490   H      H      H    H    O    --   T.sup.139                             1491   H      H      H    H    NH   --   T.sup.140                             1492   H      H      H    H    O    --   T.sup.140                             1493   H      H      H    H    NH   --   T.sup.141                             1494   H      H      H    H    O    --   T.sup.141                             1495   H      H      H    H    NH   --   T.sup.142                             1496   H      H      H    H    O    --   T.sup.142                             1497   H      H      H    H    NH   --   T.sup.143                             1498   H      H      H    H    O    --   T.sup.143                             1499   H      H      H    H    NH   --   T.sup.144                             1500   H      H      H    H    O    --   T.sup.144                             1501   H      H      H    H    NH   --   T.sup.145                             1502   H      H      H    H    O    --   T.sup.145                             1503   H      H      H    H    NH   --   T.sup.146                             1504   H      H      H    H    O    --   T.sup.146                             1505   H      H      H    H    NH   --   T.sup.147                             1506   H      H      H    H    O    --   T.sup.147                             1507   H      H      H    H    NH   --   T.sup.148                             1508   H      H      H    H    O    --   T.sup.148                             1509   H      H      H    H    NH   --   T.sup.149                             1510   H      H      H    H    O    --   T.sup.149                             1511   H      H      H    H    NH   --   T.sup.150                             1512   H      H      H    H    O    --   T.sup.150                             1513   H      H      H    H    NH   --   T.sup.151                                                                           188-189                          1514   H      H      H    H    O    --   T.sup.151                                                                           118                              1515   H      H      H    H    NH   --   T.sup.152                             1516   H      H      H    H    O    --   T.sup.152                             1517   H      H      H    H    NH   --   T.sup.153                             1518   H      H      H    H    O    --   T.sup.153                             1519   H      H      H    H    NH   --   T.sup.154                             1520   H      H      H    H    O    --   T.sup.154                             1521   H      H      H    H    NH   --   T.sup.155                             1522   H      H      H    H    O    --   T.sup.155                             1523   H      H      H    H    NH   --   T.sup.156                             1524   H      H      H    H    O    --   T.sup.156                             1525   H      H      H    H    NH   --   T.sup.157                             1526   H      H      H    H    O    --   T.sup.157                             1527   H      H      H    H    NH   --   T.sup.158                             1528   H      H      H    H    O    --   T.sup.158                             1529   H      H      H    H    NH   --   T.sup.159                             1530   H      H      H    H    O    --   T.sup.159                             1531   H      H      H    H    NH   --   T.sup.160                                                                           78-80                            1532   H      H      H    H    O    --   T.sup.160                             1533   H      H      H    H    NH   --   T.sup.161                                                                           92-94                            1534   H      H      H    H    O    --   T.sup.161                             1535   H      H      H    H    NH   --   T.sup.162                             1536   H      H      H    H    O    --   T.sup.162                             1537   H      H      H    H    NH   --   T.sup.163                             1538   H      H      H    H    O    --   T.sup.163                             1539   H      H      H    H    NH   --   T.sup.164                             1540   H      H      H    H    O    --   T.sup.164                             1541   H      H      H    H    NH   --   T.sup.165                             1542   H      H      H    H    O    --   T.sup.165                             1543   H      H      H    H    NH   --   T.sup.166                             1544   H      H      H    H    O    --   T.sup.166                             1545   H      H      H    H    NH   --   T.sup.167                             1546   H      H      H    H    O    --   T.sup.167                             1547   H      H      H    H    NH   --   T.sup.168                             1548   H      H      H    H    O    --   T.sup.168                             1549   H      H      H    H    NH   --   T.sup.169                             1550   H      H      H    H    O    --   T.sup.169                             1551   H      H      H    H    NH   --   T.sup.170                             1552   H      H      H    H    O    --   T.sup.170                             1553   H      H      H    H    NH   --   T.sup.171                             1554   H      H      H    H    O    --   T.sup.171                             1555   H      H      H    H    NH   --   T.sup.172                             1556   H      H      H    H    O    --   T.sup.172                             1557   H      H      H    H    NH   --   T.sup.173                             1558   H      H      H    H    O    --   T.sup.173                             1559   H      H      H    H    NH   --   T.sup.174                             1560   H      H      H    H    O    --   T.sup.174                             1561   H      H      H    H    NH   --   T.sup.175                             1562   H      H      H    H    O    --   T.sup.175                             1563   H      H      H    H    NH   --   T.sup.176                             1564   H      H      H    H    O    --   T.sup.176                             1565   H      H      H    H    NH   --   T.sup.177                             1566   H      H      H    H    O    --   T.sup.177                             1567   H      H      H    H    NH   --   T.sup.178                             1568   H      H      H    H    O    --   T.sup.178                             1569   H      H      H    H    NH   --   T.sup.179                             1570   H      H      H    H    O    --   T.sup.179                             1571   H      H      H    H    NH   --   T.sup.180                             1572   H      H      H    H    O    --   T.sup.180                             1573   H      H      H    H    NH   --   T.sup.181                             1574   H      H      H    H    O    --   T.sup.181                             1575   H      H      H    H    NH   --   T.sup.182                             1576   H      H      H    H    O    --   T.sup.182                             1577   H      H      H    H    NH   --   T.sup.183                             1578   H      H      H    H    O    --   T.sup.183                             1579   H      H      H    H    NH   --   T.sup.184                             1580   H      H      H    H    O    --   T.sup.184                             1581   H      H      H    H    NH   --   T.sup.185                             1582   H      H      H    H    O    --   T.sup.185                             1583   H      H      H    H    NH   --   T.sup.186                             1584   H      H      H    H    O    --   T.sup.186                             1585   H      H      H    H    NH   --   T.sup.187                             1586   H      H      H    H    O    --   T.sup.187                             1587   H      H      H    H    NH   --   T.sup.188                             1588   H      H      H    H    O    --   T.sup.188                             1589   H      H      H    H    NH   --   T.sup.189                             1590   H      H      H    H    O    --   T.sup.189                             1591   H      H      H    H    NH   --   T.sup.190                             1592   H      H      H    H    O    --   T.sup.190                             1593   H      H      H    H    NH   --   T.sup.191                             1594   H      H      H    H    O    --   T.sup.191                             1595   H      H      H    H    NH   --   T.sup.192                             1596   H      H      H    H    O    --   T.sup.192                             1597   H      H      H    H    NH   --   T.sup.193                             1598   H      H      H    H    O    --   T.sup.193                             1599   H      H      H    H    NH   --   T.sup.194                             1600   H      H      H    H    O    --   T.sup.194                             1601   H      H      H    H    NH   --   T.sup.195                             1602   H      H      H    H    O    --   T.sup.195                             1603   H      H      H    H    NH   --   T.sup.196                             1604   H      H      H    H    O    --   T.sup.196                             1605   H      H      H    H    NH   --   T.sup.197                             1606   H      H      H    H    O    --   T.sup.197                             1607   H      H      H    H    NH   --   T.sup.198                             1608   H      H      H    H    O    --   T.sup.198                             1609   H      H      H    H    NH   --   T.sup.199                             1610   H      H      H    H    O    --   T.sup.199                             1611   H      H      H    H    NH   --   T.sup.200                             1612   H      H      H    H    O    --   T.sup.200                             1613   H      H      H    H    NH   --   T.sup.201                             1614   H      H      H    H    O    --   T.sup.201                             1615   H      H      H    H    NH   --   T.sup.202                             1616   H      H      H    H    O    --   T.sup.202                             1617   H      H      H    H    NH   --   T.sup.203                             1618   H      H      H    H    O    --   T.sup.203                             1619   H      H      H    H    NH   --   T.sup.204                             1620   H      H      H    H    O    --   T.sup.204                             1621   H      H      H    H    NH   --   T.sup.205                             1622   H      H      H    H    O    --   T.sup.205                             1623   H      H      H    H    NH   --   T.sup.206                             1624   H      H      H    H    O    --   T.sup.206                             1625   H      H      H    H    NH   --   T.sup.207                             1626   H      H      H    H    O    --   T.sup.207                             1627   H      H      H    H    NH   --   T.sup.208                             1628   H      H      H    H    O    --   T.sup.208                             1629   H      H      H    H    NH   --   T.sup.209                             1630   H      H      H    H    O    --   T.sup.209                             1631   H      H      H    H    NH   --   T.sup.210                             1632   H      H      H    H    O    --   T.sup.210                             1633   H      H      H    H    NH   --   T.sup.211                             1634   H      H      H    H    O    --   T.sup.211                             1635   H      H      H    H    NH   --   T.sup.212                             1636   H      H      H    H    O    --   T.sup.212                             1637   H      H      H    H    NH   --   T.sup.213                             1638   H      H      H    H    O    --   T.sup.213                             1639   H      H      H    H    NH   --   T.sup.214                             1640   H      H      H    H    O    --   T.sup.214                             1641   H      H      H    H    NH   --   T.sup.215                             1642   H      H      H    H    O    --   T.sup.215                             1643   H      H      H    H    NH   --   T.sup.216                             1644   H      H      H    H    O    --   T.sup.216                             1645   H      H      H    H    NH   --   T.sup.217                             1646   H      H      H    H    O    --   T.sup.217                             1647   H      H      H    H    NH   --   T.sup.218                             1648   H      H      H    H    O    --   T.sup.218                             1649   H      H      H    H    NH   --   T.sup.219                             1650   H      H      H    H    O    --   T.sup.219                             1651   H      H      H    H    NH   --   T.sup.220                             1652   H      H      H    H    O    --   T.sup.220                             1653   H      H      H    H    NH   --   T.sup.221                             1654   H      H      H    H    O    --   T.sup.221                             1655   H      H      H    H    NH   --   T.sup.222                             1656   H      H      H    H    O    --   T.sup.222                             1657   H      H      H    H    NH   --   T.sup.223                             1658   H      H      H    H    O    --   T.sup.223                             1659   H      H      H    H    NH   --   T.sup.224                             1660   H      H      H    H    O    --   T.sup.224                             1661   H      H      H    H    NH   --   T.sup.225                             1662   H      H      H    H    O    --   T.sup.225                             1663   H      H      H    H    NH   --   T.sup.226                             1664   H      H      H    H    O    --   T.sup.226                             1665   H      H      H    H    NH   --   T.sup.227                             1666   H      H      H    H    O    --   T.sup.227                             1667   H      H      H    H    NH   --   T.sup.228                             1668   H      H      H    H    O    --   T.sup.228                             1669   H      H      H    H    NH   --   T.sup.229                             1670   H      H      H    H    O    --   T.sup.229                             1671   H      H      H    H    NH   --   T.sup.230                             1672   H      H      H    H    O    --   T.sup.230                             1673   H      H      H    H    NH   --   T.sup.231                             1674   H      H      H    H    O    --   T.sup.231                             1675   H      H      H    H    NH   --   T.sup.232                             1676   H      H      H    H    O    --   T.sup.232                             1677   H      H      H    H    NH   --   T.sup.233                             1678   H      H      H    H    O    --   T.sup.233                             1679   H      H      H    H    NH   --   T.sup.234                             1680   H      H      H    H    O    --   T.sup.234                             1681   H      H      H    H    NH   --   T.sup.235                             1682   H      H      H    H    O    --   T.sup.235                             1683   H      H      H    H    NH   --   T.sup.236                             1684   H      H      H    H    O    --   T.sup.236                             1685   H      H      H    H    NH   --   T.sup.237                             1686   H      H      H    H    O    --   T.sup.237                             1687   H      H      H    H    NH   --   T.sup.238                             1688   H      H      H    H    O    --   T.sup.238                             1689   H      H      H    H    NH   --   T.sup.239                             1690   H      H      H    H    O    --   T.sup.239                             1691   H      H      H    H    NH   --   T.sup.240                             1692   H      H      H    H    O    --   T.sup.240                             1693   H      H      H    H    NH   --   T.sup.241                             1694   H      H      H    H    O    --   T.sup.241                             1695   H      H      H    H    NH   --   T.sup.242                             1696   H      H      H    H    O    --   T.sup.242                             1697   H      H      H    H    NH   --   T.sup.243                             1698   H      H      H    H    O    --   T.sup.243                             1699   H      H      H    H    NH   --   T.sup.244                             1700   H      H      H    H    O    --   T.sup.244                             1701   H      H      H    H    NH   --   T.sup.245                             1702   H      H      H    H    O    --   T.sup.245                             1703   H      H      H    H    NH   --   T.sup.246                             1704   H      H      H    H    O    --   T.sup.246                             1705   H      H      H    H    NH   --   T.sup.247                             1706   H      H      H    H    O    --   T.sup.247                             1707   H      H      H    H    NH   --   T.sup.248                             1708   H      H      H    H    O    --   T.sup.248                             ______________________________________                                    

                  TABLE III                                                        ______________________________________                                          ##STR263##                                                                    Example                                                                        No.    A       B       X     E    Q     M.p. [°C.]                      ______________________________________                                         1709   CH      S       NH    --   T.sup.7                                      1710   "       "       O     --   T.sup.7                                      1711   S       CH      NH    --   T.sup.7                                      1712   "       "       O     --   T.sup.7                                      1713   CH      S       NH    --   T.sup.9                                      1714   S       CH      O     --   T.sup.9                                      1715   S       CH      NH    --   T.sup.9                                      1716   "       "       O     --   T.sup.9                                      1717   CH      S       NH    --   T.sup.8                                      1718   "       "       O     --   T.sup.8                                      1719   S       CH      NH    --   T.sup.8                                      1720   "       "       O     --   T.sup.8                                      1721   CH      S       NH    --   T.sup.4                                      1722   "       "       O     --   T.sup.4                                      1723   S       CH      NH    --   T.sup.4                                      1724   "       "       O     --   T.sup.4                                      1725   CH      S       NH    --   T.sup.10                                     1726   "       "       O     --   T.sup.10                                     1727   S       CH      NH    --   T.sup.10                                     1728   S       CH      O     --   T.sup.10                                     1729   CH      S       NH    --   T.sup.11                                     1730   "       "       O     --   T.sup.11                                     1731   S       CH      NH    --   T.sup.11                                     1732   "       "       O     --   T.sup.11                                     1733   CH      S       NH    --   T.sup.12                                     1734   "       "       O     --   T.sup.12                                     1735   S       CH      NH    --   T.sup.12                                     1736   "       "       O     --   T.sup.12                                     1737   CH      S       NH    --   T.sup.14                                     1738   "       "       O     --   T.sup.14                                     1739   S       CH      NH    --   T.sup.14                                     1740   "       "       "     --   T.sup.14                                     1741   CH      S       NH         T.sup.23                                                                             118-120                                1742   "       "       O     --   T.sup.23                                     1743   S       CH      NH    --   T.sup.23                                     1744   "       "       O     --   T.sup.23                                     1745   CH      S       NH         T.sup.58                                     1746   "       "       O          T.sup.58                                     1747   S       CH      NH         T.sup.58                                     1748   "       "       O          T.sup.58                                     ______________________________________                                    

                  TABLE IV                                                         ______________________________________                                          ##STR264##                                                                    Example                                                                        No.      X          R         M.p. [°C.]                                ______________________________________                                         1749     NH                                                                                         ##STR265##                                                                              238-240                                          1750     NH                                                                                         ##STR266##                                                                              152-154                                          ______________________________________                                    

                  TABLE V                                                          ______________________________________                                          ##STR267##                                                                    Example                                                                        No.         X                  M.p. [°C.]                               ______________________________________                                         1751        NH        T.sup.4                                                  1752        NH        T.sup.7                                                  1753        NH        T.sup.8                                                  1754        NH        T.sup.9                                                  1755        O         T.sup.9                                                  1756        NH        T.sup.10                                                 1757        NH        T.sup.12                                                 1758        NH        T.sup.14                                                 1759        NH        T.sup.23                                                 1760        O         T.sup.23                                                 1761        NH        T.sup.66                                                 1762        NH        T.sup.68                                                 1763        NH        T.sup.70                                                 1764        O         T.sup.70                                                 1765        NH        T.sup.76                                                 1766        O         T.sup.76                                                 ______________________________________                                    

                  TABLE VI                                                         ______________________________________                                          ##STR268##                                                                    Example                                                                        No.         X                  M.p. [°C.]                               ______________________________________                                         1767        NH        T.sup.4                                                  1768        NH        T.sup.7                                                  1769        NH        T.sup.8                                                  1770        NH        T.sup.9                                                  1771        O         T.sup.9                                                  1772        NH        T.sup.10                                                 1773        NH        T.sup.12                                                 1774        NH        T.sup.14                                                 1775        NH        T.sup.23                                                 1776        O         T.sup.23                                                 1777        NH        T.sup.66                                                 1778        NH        T.sup.68                                                 1779        NH        T.sup.20                                                 1780        O         T.sup.20                                                 1781        NH        T.sup.76                                                 1782        O         T.sup.76                                                 ______________________________________                                    

                  TABLE VII                                                        ______________________________________                                          ##STR269##                                                                    Example                                                                        No.         X                  M.p. [°C.]                               ______________________________________                                         1783        NH        T.sup.4                                                  1784        NH        T.sup.7                                                  1785        NH        T.sup.8                                                  1786        NH        T.sup.9                                                  1787        O         T.sup.9                                                  1788        NH        T.sup.10                                                 1789        NH        T.sup.12                                                 1790        NH        T.sup.14                                                 1791        NH        T.sup.23                                                 1792        O         T.sup.23                                                 1793        NH        T.sup.66                                                 1794        NH        T.sup.68                                                 1795        NH        T.sup.70                                                 1796        O         T.sup.70                                                 1797        NH        T.sup.76                                                 1798        O         T.sup.76                                                 ______________________________________                                    

                  TABLE VIII                                                       ______________________________________                                          ##STR270##                                                                    Example                                                                        No.         X                  M.p. [°C.]                               ______________________________________                                         1799        NH        T.sup.4                                                  1800        NH        T.sup.7                                                  1801        NH        T.sup.8                                                  1802        NH        T.sup.9                                                  1803        O         T.sup.9                                                  1804        NH        T.sup.10                                                 1805        NH        T.sup.12                                                 1806        NH        T.sup.14                                                 1807        NH        T.sup.23                                                 1808        O         T.sup.23                                                 1809        NH        T.sup.66                                                 1810        NH        T.sup.68                                                 1811        NH        T.sup.70                                                 1812        O         T.sup.70                                                 1813        NH        T.sup.76                                                 1814        O         T.sup.76                                                 ______________________________________                                     

We claim:
 1. A compound of the formula I ##STR271## in which R¹ is hydrogen, halogen, (C₁ -C₄)-alkyl or (C₃ -C₆)-cycloalkyl,R² is hydrogen, (C₁ -C₄)-alkyl, halogen, (C₁ -C₄)-haloalkyl, (C₁ -C₄)-alkoxy, (C₁ -C₄)-haloalkoxy, (C₁ -C₄)-alkoxy-(C₁ -C₄)-alkyl, (C₁ -C₄)-alkylthio, (C₁ -C₄)-alkylthio-(C₁ -C₄)-alkyl, (C₁ -C₄)-alkyl-amino or di-(C₁ -C₄)-alkylamino, R³ is hydrogen, (C₁ -C₄)-alkyl, (C₁ -C₄)-alkoxy, (C₁ -C₄)-haloalkoxy, halogen, (C₁ -C₄)-alkylthio, amino, (C₁ -C₄)-alkylamino or di-(C₁ -C₄)-alkyl-amino or R² and R³ together with the carbon atoms to which they are bonded form an unsaturated 5- or 6-membered carbocyclic ring which, if it is a 5-membered ring, can contain an oxygen atom in place of CH₂ and which 5- or 6-membered ring is optionally substituted by 1, 2 or 3 identical or different radicals, these radicals being (C₁ -C₄)-alkyl, (C₁ -C₄)-alkoxy, (C₁ -C₄)-haloalkyl, (C₁ -C₄)-haloalkoxy or halogen, or if it is a 5-membered ring, can also contain a sulfur atom in place of CH₂ and which ring is optionally substituted by 1, 2 or 3 identical or different radicals, these radicals being (C₁ -C₆)alkyl, (C₁ -C₄)-alkoxy, (C₁ -C₄)-haloalkyl, or (C₁ -C₄)-haloalkoxy, or R² and R³ together with the carbon atoms to which they are bonded form a saturated 5-, 6- or 7-membered carbocyclic ring which can contain an oxygen or sulfur atom in place of CH₂ and which is optionally substituted by 1, 2 or 3 (C₁ -C₄)-alkyl groups, X is NH or oxygen, E is a direct bond or a straight-chain or branched (C₁ -C₄)-alkanediyl group, Q has the meaning Q¹ and Q¹ is a cycloalkyl group of the formula II ##STR272## in which n is an integer from 2 to 7, R⁴ and R⁵ are identical or different and are in each case hydrogen, (C₁ -C₁₂)-alkyl, (C₃ -C₈)-cycloalkyl, (C₃ -C₈)-cycloalkyl-(C₁ -C₄) -alkyl, (C₁ -C₄)-alkoxy, (C₃ -C₈)-cycloalkoxy, (C₁ -C₄)-alkoxy-(C₁ -C₄)-alkyl, (C₃ -C₈)-cycloalkyl-(C₁ -C₄)-alkoxy, tri-(C₁ -C₄)-alkylsilyl, di-(C₁ -C₈)-alkyl-(C₃ -C₈)-cycloalkyl-silyl, di-(C₁ -C₈)-alkyl-(phenyl-(C₁ -C₄)-alkyl)-silyl, di-(C₁ -C₈)-alkyl-(C₁ -C₄)-haloalkylsilyl, dimethylphenyl silyl, (C₁ -C₄)-haloalkyl, halogen, (C₁ -C₄)-haloalkoxy, phenyl, phenyl-(C₁ -C₄)-alkyl, benzyloxy, benzyloxy-(C₁ -C₄)-alkyl, benzylthio, phenylthio or phenoxy, it being possible for the phenyl rings in the seven last-mentioned radicals to be unsubstituted or provided with one or two substituents and these substituents are identical or different and can be in each case (C₁ -C₈)-alkyl, (C₁ -C₈)-cycloalkyl, (C₁ -C₄)-haloalkyl, halogen, (C₁ -C₄)-dialkylamino, (C₁ -C₄)-alkylthio, (C₁ -C₈)-alkoxy, (C₁ -C₄)-haloalkoxy, (C₁ -C₄)-alkoxy-(C₁ -C₄)-alkoxy, H₅ C₂ --O--[CH₂ --CH₂ --O]_(y), 2- (tetrahydro-2H-pyran-2-yloxy)-ethoxy, (C₂ -C₈)-alkenyl, (C₂ -C₈)-alkynyl, benzyloxy which in the phenyl radical optionally carries one or two identical or different substituents selected from the group comprising (C₁ -C₄)-alkyl, (C₁ -C₄)-haloalkyl, (C₁ -C₄)-alkoxy, (C₁ -C₄)-haloalkoxy and halogen, or tri-(C₁ -C₄)-alkylsilylmethoxy, (C₃ -C₈)-cycloalkyl-(C₁ -C₄)-alkoxy, 1,3 -dioxolan-2-ylmethoxy, tetrahydrofuran-2 -ylmethoxy or tetrahydro-2H-pyran-2-ylmethoxy, where, both R⁴ and R⁵ do not coincidentally denote hydrogen, and where, in two adjacent substituents which are identical or different and selected from the group comprising (C₁ -C₈)-alkyl and (C₁ -C₈)-alkoxy, in each case one hydrogen atom can be replaced by a joint carbon-carbon bond which links these two substituents, or R⁴ and R⁵ together with the cycloalkyl group form a 3-8-membered spirocyclic ring system which can contain oxygen or sulfur in place of one or two CH₂ groups or R⁴ and R⁵ together with the carbon atoms carrying them form a fused 5- or 6-membered carbocycle, y is 2, 3 or 4, or Q has the meaning Q² and Q² is a group of the formula III ##STR273## in which R⁶ is a group of the formula Z--W and Z is a direct bond or carbonyl or sulfonyl and W is a phenyl, naphthyl, or biphenyl or heteroaryl selected from the group consisting of 2-pyridyl, 2-quinoxalinyl and 2-pyrimidinyl which phenyl, naphthyl, biphenyl or heteroaryl can be unsubstituted or provided with one or two substituents and these substituents are identical or different and are in each case (C₁ -C₈)-alkyl, (C₃ -C₈) -cycloalkyl, trifluoromethyl, halogen, (C₁ -C₄)-alkoxy, (C₁ -C₄)-dialkylamino or (C₁ -C₄)-alkylthio, or acid addition salts thereof.
 2. A compound of the formula I as claimed in claim 1, in whichR¹ is hydrogen, methyl or cyclopropyl, R² is (C₁ -C₄)-alkyl, chlorine, methoxy, ethoxy or methoxymethyl, R³ is hydrogen, (C₁ -C₃)-alkyl, methoxy, ethoxy or halogen or R² and R³ together with the carbon atoms to which they are bonded form an unsaturated 5- or 6-membered ring which can contain an oxygen or sulfur atom, or R² and R³ together with the carbon atoms to which they are bonded form a saturated 5- or 6-membered ring which can contain a sulfur atom, Q has the meaning Q¹ or Q², or acid addition salts thereof.
 3. A compound of the formula I as claimed in claim 1 or 2, in whichR¹ is hydrogen or methyl, R² is methyl, ethyl, methoxy, ethoxy or methoxy-methyl, R³ is methyl, ethyl, methoxy, chlorine or bromine, or R² and R³ together with the carbon atoms to which they are bonded form the quinazoline system, which can be mono-, di- or trisubstituted by fluorine, chlorine, bromine, methyl and/or methoxy, or R² and R³ together with the carbon atoms to which they are bonded form a saturated 6-membered ring which can contain a sulfur atom and Q has the meaning Q¹ or Q², or acid addition salts thereof.
 4. A compound of the formula I as claimed in claim 1, in whichE is a direct bond, R¹ is hydrogen, R² is methyl, ethyl or methoxymethyl, R³ is chlorine, bromine or methoxy or R² and R³ together with the carbon atoms to which they are bonded form the quinazoline system which can be substituted by fluorine, chlorine, bromine or methyl, or R² and R³ together with the pyrimidine ring form the 5,6,7,8-tetrahydroquinazoline system or the 5,6-dihydro-7H-thiopyranopyrimidine or the 5,6-dihydro-8H-thiopyranopyrimidine system and Q has the meaning Q¹ or Q², or acid addition salts thereof.
 5. A compound of the formula I as claimed in claim 1, in whichR¹ is hydrogen, R² is methoxymethyl and R³ is methoxy or R² is methyl or ethyl and R³ is chlorine or bromine or R² and R³ together with the carbon atom to which they are bonded form a quinazoline system which is substituted by fluorine, chlorine or methyl, or form a 5,6,7,8-tetrahydroquinazolin system and Q has the meaning Q¹, or acid addition salts thereof.
 6. A compound of the formula I as claimed in claim 1, in whichE is a direct bond, R¹ is hydrogen, R² is methoxymethyl and R³ is methoxy or R² is ethyl and R³ is chlorine or R² and R³ together with the carbon atom to which they are bonded form a quinazoline or a 5,6,7,8-tetrahydroquinazoline system and Q¹ is a cycloalkyl group of the formula II which is substituted in the 3- or 4-position and in which n is 4 or 5, R is (C₃ -C₈)-alkyl, cyclopentyl, cyclohexyl, phenyl or phenoxy, it being possible for the two last-mentioned radicals to be unsubstituted or provided with one or two substituents which can be identical or different and which are fluorine, chlorine, bromine, (C₁ -C₄)-alkyl, (C₁ -C₄)-alkoxy, trifluoromethyl, (C₁ -C₄)-haloalkoxy, cyclohexyl, 2-ethoxyethoxy, methylthio or dimethylamino, and R⁵ is hydrogen, or acid addition salts thereof.
 7. A compound of the formula I as claimed in claim 1, in whichE is a direct bond, R¹ is hydrogen, R² is methoxymethyl and R³ is methoxy or R² is ethyl and R³ is chlorine, or R² and R³ together with the carbon atoms to which they are bonded form a quinazoline or a 5,6,7,8-tetrahydroquinazoline system, Q has the meaning Q¹ and Q¹ is cyclohexyl which is substituted in the 4-position, and E and the substituent in the 4-position of the cyclohexyl are in the cis-position relative to each other, or acid addition salts thereof.
 8. An insecticidal or acaricidal composition which comprises an effective amount of a compound of the formula I as claimed in claim 1 and suitable formulation auxiliaries.
 9. An fungicidal composition which comprises an effective amount of a compound of the formula I as claimed in claim 1 and suitable formulation auxiliaries.
 10. An nematocidal composition which comprises an effective amount of a compound of the formula I as claimed in claim 1 and suitable formulation auxiliaries.
 11. A method of controlling insect pests and acarids, which comprises applying an effective amount of a compound of the formula I as claimed in claim 1 to these insect pests or acarids or to the plants, areas or substrates which are infested with them.
 12. A method of controlling harmful fungi, which comprises applying an effective amount of a compound of the formula I as claimed in claim 1 to these harmful fungi or to the plants, areas or substrates infected by them.
 13. A method of controlling nematodes, which comprises applying an effective amount of a compound of the formula I as claimed in claim 1 these nematodes or to the plants, areas or substrates infested with them.
 14. A method of controlling endo- and/or ectoparasites, which comprises administering an effective amount of a compound of the formula I as claimed in claim 1 to the animal infected by them.
 15. A composition for controlling endo- and ecto-parasites which comprises an effective amount of a compound of the formula I as claimed in claim 1 and suitable formulation auxiliaries.
 16. A pharmaceutical preparation comprising an effective amount of at least one compound of the formula I as claimed in claim 1 or a physiologically acceptable salt thereof and a physiologically acceptable excipient. 